TY - JOUR
T1 - Dietary predictors of arterial stiffness in a cohort with type 1 and type 2 diabetes
AU - Petersen, K. S.
AU - Keogh, J. B.
AU - Meikle, P. J.
AU - Garg, M. L.
AU - Clifton, P. M.
N1 - Funding Information:
PJM is supported by a NHMRC senior research fellowship (1042095). This work was supported by the OIS Program of the Victorian Government, Australia . JBK is a Fellow of the South Australian Cardiovascular Research Development Program funded by the Heart Foundation and the Government of South Australia . PMC is supported by a NHMRC Principal Research Fellowship . KSP is funded by an Australian Postgraduate Award + UniSA Rural and Isolated Top-up Scholarship . This research was jointly funded through these fellowships and the University of South Australia .
Publisher Copyright:
© 2014.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95% CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95% CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95% CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.
AB - Objective: To determine the dietary predictors of central blood pressure, augmentation index and pulse wave velocity (PWV) in subjects with type 1 and type 2 diabetes. Methods: Participants were diagnosed with type 1 or type 2 diabetes and had PWV and/or pulse wave analysis performed. Dietary intake was measured using the Dietary Questionnaire for Epidemiological Studies Version 2 Food Frequency Questionnaire. Serum lipid species and carotenoids were measured, using liquid chromatography electrospray ionization-tandem mass spectrometry and high performance liquid chromatography, as biomarkers of dairy and vegetable intake, respectively. Associations were determined using linear regression adjusted for potential confounders. Results: PWV ( n=95) was inversely associated with reduced fat dairy intake ( β=-0.01; 95% CI-0.02,-0.01; p=0<0.05) in particular yoghurt consumption ( β=-0.04; 95% CI-0.09,-0.01; p=0<0.05) after multivariate adjustment. Total vegetable consumption was negatively associated with PWV in the whole cohort after full adjustment ( β=-0.04; 95% CI-0.07,-0.01; p<0.05). Individual lipid species, particularly those containing 14:0, 15:0, 16:0, 17:0 and 17:1 fatty acids, known to be of ruminant origin, in lysophosphatidylcholine, cholesterol ester, diacylglycerol, phosphatidylcholine, sphingomyelin and triacylglycerol classes were positively associated with intake of full fat dairy, after adjustment for multiple comparisons. However, there was no association between serum lipid species and PWV. There were no dietary predictors of central blood pressure or augmentation index after multivariate adjustment. Conclusion: In this cohort of subjects with diabetes reduced fat dairy intake and vegetable consumption were inversely associated with PWV. The lack of a relationship between serum lipid species and PWV suggests that the fatty acid composition of dairy may not explain the beneficial effect.
KW - Arterial stiffness
KW - Carotenoids
KW - Dairy
KW - Diabetes
KW - Lipidomics
KW - Pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84919782497&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2014.12.012
DO - 10.1016/j.atherosclerosis.2014.12.012
M3 - Article
C2 - 25528424
AN - SCOPUS:84919782497
SN - 0021-9150
VL - 238
SP - 175
EP - 181
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -
