Dietary patterns and their associations with age-related macular degeneration: The Melbourne collaborative cohort study

Fakir M Amirul Islam, Elaine W Chong, Allison M Hodge, Robyn H Guymer, Khin Zaw Aung, Galina A Makeyeva, Paul N Baird, John L Hopper, Dallas R English, Graham G Giles, Liubov D. Robman

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55 Citations (Scopus)


Objective To evaluate the association between dietary patterns and age-related macular degeneration (AMD). Design Food frequency data were collected from Melbourne Collaborative Cohort Study (MCCS) participants at the baseline study in 1990-1994. During follow-up in 2003-2007, retinal photographs were taken and evaluated for AMD. Participants At baseline, 41 514 participants aged 40 to 70 years and born in Australia or New Zealand (69 ), or who had migrated from the United Kingdom, Italy, Greece, or Malta (31 ) were recruited. Of these, 21 132 were assessed for AMD prevalence at follow-up. Methods Principal component analysis was used to identify dietary patterns (Factors F1-6) among the food items. Logistic regression was used to assess associations of dietary patterns with AMD. Main Outcome Measures Odds ratios (ORs) for early stages and advanced AMD in association with dietary patterns. Results A total of 2508 participants (12.8 ) had early stages of AMD, and 108 participants (0.6 ) had advanced AMD. Six factors characterized by predominant intakes of fruits (F1); vegetables (F2); grains, fish, steamed or boiled chicken, vegetables, and nuts (F3); red meat (F4); processed foods comprising cakes, sweet biscuits, and desserts (F5); and salad (F6) were identified. Higher F3 scores were associated with a lower prevalence of advanced AMD (fourth vs. first quartile) (OR, 0.49; 95 confidence interval [CI], 0.28-0.87), whereas F4 scores greater than the median were associated with a higher prevalence of advanced AMD (OR, 1.46; 95 CI, 1.0-2.17). Conclusions Rather than specific individual food items, these factors represent a broader picture of food consumption. A dietary pattern high in fruits, vegetables, chicken, and nuts and a pattern low in red meat seems to be associated with a lower prevalence of advanced AMD. No particular food pattern seemed to be associated with the prevalence of the earliest stages of AMD.
Original languageEnglish
Pages (from-to)1428-1434.e2
Number of pages9
Issue number7
Publication statusPublished - 2014
Externally publishedYes

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