Abstract
Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women. Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning. Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β =.10, P =.03). Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.
Original language | English |
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Pages (from-to) | 535-541 |
Number of pages | 7 |
Journal | Alzheimer's & Dementia: Translational Research & Clinical Interventions |
Volume | 4 |
DOIs | |
Publication status | Published - 2018 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Biomarkers
- Diet
- Dietary pattern
- Factor analysis
- Neuropathology
- Nutrition
- Women
- β-amyloid protein