Dietary patterns and β-amyloid deposition in aging Australian women

Edward Hill, Peter Clifton, Alicia M. Goodwill, Lorraine Dennerstein, Stephen Campbell, Cassandra Szoeke

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women. Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning. Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β =.10, P =.03). Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease.

Original languageEnglish
Pages (from-to)535-541
Number of pages7
JournalAlzheimer's & Dementia: Translational Research & Clinical Interventions
Volume4
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Diet
  • Dietary pattern
  • Factor analysis
  • Neuropathology
  • Nutrition
  • Women
  • β-amyloid protein

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