Abstract
Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N = 41,513) for over 20 years and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221). Energy-adjusted dietary intakes of B vitamins (B1, B2, B3, B5, B6, B8, B9 and B12) and methionine were estimated from a 121-item food frequency questionnaire administered at baseline (1990–1994), using the residuals method. We used Cox regression models to compute hazard ratios (HRs) of UCC risk per standard deviation (SD) of log-transformed nutrient intakes and 95% confidence intervals, adjusted for potential confounders. We investigated associations by tumor subtype, and tested interactions with sex, country of birth, smoking and alcohol drinking. The risk of UCC appeared not to be associated with intake of B-group vitamins or methionine, and findings were consistent across tumor subtypes and across demographic and lifestyle characteristics of the participants. A potential interaction between vitamin B1 and alcohol drinking was observed (all participants: HR per 1 SD = 0.99 (0.91–1.09), never drinkers: HR = 0.81 (0.69–0.97), p-interaction = 0.02), which needs to be confirmed by other studies. Our findings do not indicate that dietary intake of nutrients involved in one-carbon metabolism are associated with UCC risk.
| Original language | English |
|---|---|
| Pages (from-to) | 298-306 |
| Number of pages | 9 |
| Journal | International Journal of Cancer |
| Volume | 143 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 15 Jul 2018 |
Keywords
- B vitamin
- bladder cancer
- diet
- folate
- methionine
- one-carbon metabolism
- urothelial cell carcinoma
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Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma : A prospective cohort study. / Dugué, Pierre Antoine; Brinkman, Maree T.; Hodge, Allison M.; Bassett, Julie K.; Bolton, Damien; Longano, Anthony; Hopper, John L.; Southey, Melissa C.; English, Dallas R.; Milne, Roger L.; Giles, Graham G.
In: International Journal of Cancer, Vol. 143, No. 2, 15.07.2018, p. 298-306.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma
T2 - A prospective cohort study
AU - Dugué, Pierre Antoine
AU - Brinkman, Maree T.
AU - Hodge, Allison M.
AU - Bassett, Julie K.
AU - Bolton, Damien
AU - Longano, Anthony
AU - Hopper, John L.
AU - Southey, Melissa C.
AU - English, Dallas R.
AU - Milne, Roger L.
AU - Giles, Graham G.
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N = 41,513) for over 20 years and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221). Energy-adjusted dietary intakes of B vitamins (B1, B2, B3, B5, B6, B8, B9 and B12) and methionine were estimated from a 121-item food frequency questionnaire administered at baseline (1990–1994), using the residuals method. We used Cox regression models to compute hazard ratios (HRs) of UCC risk per standard deviation (SD) of log-transformed nutrient intakes and 95% confidence intervals, adjusted for potential confounders. We investigated associations by tumor subtype, and tested interactions with sex, country of birth, smoking and alcohol drinking. The risk of UCC appeared not to be associated with intake of B-group vitamins or methionine, and findings were consistent across tumor subtypes and across demographic and lifestyle characteristics of the participants. A potential interaction between vitamin B1 and alcohol drinking was observed (all participants: HR per 1 SD = 0.99 (0.91–1.09), never drinkers: HR = 0.81 (0.69–0.97), p-interaction = 0.02), which needs to be confirmed by other studies. Our findings do not indicate that dietary intake of nutrients involved in one-carbon metabolism are associated with UCC risk.
AB - Nutrients involved in one-carbon metabolism may play a role in carcinogenesis through DNA replication, repair and methylation mechanisms. Most studies on urothelial cell carcinoma (UCC) have focused on folate. We sought to examine the association between B-group vitamins and methionine intake and UCC risk, overall and by subtype, and to test whether these associations are different for population subgroups whose nutritional status may be compromised. We followed participants in the Melbourne Collaborative Cohort Study (N = 41,513) for over 20 years and observed 500 UCC cases (89% originating in the bladder; superficial: 279, invasive: 221). Energy-adjusted dietary intakes of B vitamins (B1, B2, B3, B5, B6, B8, B9 and B12) and methionine were estimated from a 121-item food frequency questionnaire administered at baseline (1990–1994), using the residuals method. We used Cox regression models to compute hazard ratios (HRs) of UCC risk per standard deviation (SD) of log-transformed nutrient intakes and 95% confidence intervals, adjusted for potential confounders. We investigated associations by tumor subtype, and tested interactions with sex, country of birth, smoking and alcohol drinking. The risk of UCC appeared not to be associated with intake of B-group vitamins or methionine, and findings were consistent across tumor subtypes and across demographic and lifestyle characteristics of the participants. A potential interaction between vitamin B1 and alcohol drinking was observed (all participants: HR per 1 SD = 0.99 (0.91–1.09), never drinkers: HR = 0.81 (0.69–0.97), p-interaction = 0.02), which needs to be confirmed by other studies. Our findings do not indicate that dietary intake of nutrients involved in one-carbon metabolism are associated with UCC risk.
KW - B vitamin
KW - bladder cancer
KW - diet
KW - folate
KW - methionine
KW - one-carbon metabolism
KW - urothelial cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85042607050&partnerID=8YFLogxK
U2 - 10.1002/ijc.31319
DO - 10.1002/ijc.31319
M3 - Article
VL - 143
SP - 298
EP - 306
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -