Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat

A. L. Murkies, C. Lombard, B. J.G. Strauss, G. Wilcox, H. G. Burger, M. S. Morton

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371 Citations (Scopus)

Abstract

Plants contain compounds with oestrogen - like action called phytoestrogens. Soy contains daidzin, a potent phytoestrogen, and wheat flour contains less potent enterolactones. We aimed to show in 58 postmenopausal women (age 54, range 30-70 years) with at least 14 hot flushes per week, that their daily diet supplemented with soy flour (n = 28) could reduce flushes compared with wheat flour (n = 30) over 12 weeks when randomised and double blind. Hot flushes significantly decreased in the soy and wheat flour groups (40% and 25% reduction, respectively <0.001 for both) with a significant rapid response in the soy flour group in 6 weeks (P < 0.001) that continued. Menopausal symptom score decreased significantly in both groups (P < 0.05). Urinary daidzein excretion confirmed compliance. Vaginal cell maturation, plasma lipids and urinary calcium remained unchanged. Serum FSH decreased and urinary hydroxyproline increased in the wheat flour group.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalMaturitas
Volume21
Issue number3
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Hot flushes
  • Menopause
  • Phytoestrogens
  • Soy flour
  • Wheat flour

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