Abstract
The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that high-fiber feeding in mice improved oral tolerance and protected from food allergy. High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate. High-fiber feeding enhanced oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103+ DC. This protection depended on vitamin A in the diet. This feeding regimen also boosted IgA production and enhanced T follicular helper and mucosal germinal center responses. Mice lacking GPR43 or GPR109A, receptors for SCFAs, showed exacerbated food allergy and fewer CD103+ DCs. Dietary elements, including fiber and vitamin A, therefore regulate numerous protective pathways in the gastrointestinal tract, necessary for immune non-responsiveness to food antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 2809-2824 |
| Number of pages | 16 |
| Journal | Cell Reports |
| Volume | 15 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 21 Jun 2016 |
Cite this
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Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways. / Tan, Jian; McKenzie, Craig; Vuillermin, Peter J.; Goverse, Gera; Vinuesa, Carola G.; Mebius, Reina E.; Macia, Laurence; Mackay, Charles R.
In: Cell Reports, Vol. 15, No. 12, 21.06.2016, p. 2809-2824.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways
AU - Tan, Jian
AU - McKenzie, Craig
AU - Vuillermin, Peter J.
AU - Goverse, Gera
AU - Vinuesa, Carola G.
AU - Mebius, Reina E.
AU - Macia, Laurence
AU - Mackay, Charles R.
PY - 2016/6/21
Y1 - 2016/6/21
N2 - The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that high-fiber feeding in mice improved oral tolerance and protected from food allergy. High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate. High-fiber feeding enhanced oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103+ DC. This protection depended on vitamin A in the diet. This feeding regimen also boosted IgA production and enhanced T follicular helper and mucosal germinal center responses. Mice lacking GPR43 or GPR109A, receptors for SCFAs, showed exacerbated food allergy and fewer CD103+ DCs. Dietary elements, including fiber and vitamin A, therefore regulate numerous protective pathways in the gastrointestinal tract, necessary for immune non-responsiveness to food antigens.
AB - The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that high-fiber feeding in mice improved oral tolerance and protected from food allergy. High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate. High-fiber feeding enhanced oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103+ DC. This protection depended on vitamin A in the diet. This feeding regimen also boosted IgA production and enhanced T follicular helper and mucosal germinal center responses. Mice lacking GPR43 or GPR109A, receptors for SCFAs, showed exacerbated food allergy and fewer CD103+ DCs. Dietary elements, including fiber and vitamin A, therefore regulate numerous protective pathways in the gastrointestinal tract, necessary for immune non-responsiveness to food antigens.
UR - http://www.scopus.com/inward/record.url?scp=84975168249&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2016.05.047
DO - 10.1016/j.celrep.2016.05.047
M3 - Article
VL - 15
SP - 2809
EP - 2824
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 12
ER -