Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism

Ava Handley, Qiuli Wu, Tessa Sherry, Rebecca Cornell, Roger Pocock

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Metabolic: homeostasis is coordinated through a robust network : of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose stress. Here, we show that Caenorhabditis elegans fed excess dietary glucose reduce insulin-1 (INS-1) expression specifically in the BAG glutamatergic sensory neurons. We demonstrate that INS-1 expression in the BAG neurons is directly controlled by the transcription factor ETS-5, which is also down-regulated by glucose. We further find that INS-1 acts exclusively from the BAG neurons, and not other INS-1-expressing neurons, to systemically inhibit fat storage via the insulin-like receptor DAF-2. Together, these findings reveal an intertissue regulatory pathway where regulation of insulin expression in a specific neuron controls systemic metabolism in response to excess dietary glucose.

Original languageEnglish
Article numbere3001655
Number of pages25
JournalPLoS Biology
Issue number5
Publication statusPublished - 20 May 2022

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