Diet-induced obesity attenuates fasting-induced hyperphagia

Dana Briggs, Moyra Lemus, Eugene Kua, Zane Andrews

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37 Citations (Scopus)


Obesity impairs arcuate (ARC) NPY/AgRP neuronal function and renders these homeostatic neurons unresponsive to the orexigenic hormone ghrelin. In the current study, we investigated the effect of diet-induced obesity (DIO) on feeding behaviour, ARC neuronal activation and mRNA expression following another orexigenic stimulus, an overnight fast. We show that 9 weeks of high-fat feeding attenuates fasting-induced hyperphagia by suppressing ARC neuronal activation and hypothalamic NPY/AgRP mRNA expression. Thus, the lack of appropriate feeding responses in DIO mice to a fast is caused by failure ARC neurons to recognize and/or respond to orexigenic cues. We propose that fasting-induced hyperphagia is regulated not by homeostatic control of appetite in DIO mice, but rather due to changes in the reward circuitry.
Original languageEnglish
Pages (from-to)620 - 626
Number of pages7
JournalJournal of Neuroendocrinology
Issue number7
Publication statusPublished - 2011

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