Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death

Gabriel Laghlali, Kate E. Lawlor, Michelle D. Tate

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection.

Original languageEnglish
Article numberE401
Number of pages23
JournalViruses
Volume12
Issue number4
DOIs
Publication statusPublished - 4 Apr 2020

Keywords

  • cell death
  • inflammation
  • Influenza A virus
  • pathogenesis

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