Abstract
The aim of this study is to assess the clinical performance of 6 different low-flux dialysis membranes under steady-state conditions in terms of urea and phosphate clearances. Ten stable hemodialysis patients were examined. The following dialyzers were studied, all in 1.5to 1.6-m2 format: cuprammonium, cellulose acetate, cellulose diacetate, hemophane, polysulfone (low-flux), and polysynthane. The following parameters were examined: urea reduction ratio, phosphate reduction ratio, 'instantaneous dialyzer clearance' for urea and phosphate, and total amount of urea and phosphate removed in the dialysate over a 1-week (three dialyses) period. Although there were differences between the membranes, all produced results within a narrow range. There was no one membrane that produced superior clearances in all categories. The cellulose acetate membrane was the least satisfactory membrane. Phosphate clearances were at best one third that of urea clearances. When choosing a low-flux dialysis membrane, urea and phosphate clearances are so similar amongst different membranes that other criteria are likely to have a greater influence on the choice of membrane.
| Original language | English |
|---|---|
| Pages (from-to) | 817-821 |
| Number of pages | 5 |
| Journal | Artificial Organs |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 4 Oct 1999 |
Keywords
- Hemodialysis
- Low-flux dialysis membranes
Cite this
}
Dialyzer performance in the clinic : Comparison of six low-flux membranes. / Kerr, Peter G.; Lo, Angela; Chin, Man Moo; Atkins, Robert C.
In: Artificial Organs, Vol. 23, No. 9, 04.10.1999, p. 817-821.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Dialyzer performance in the clinic
T2 - Comparison of six low-flux membranes
AU - Kerr, Peter G.
AU - Lo, Angela
AU - Chin, Man Moo
AU - Atkins, Robert C.
PY - 1999/10/4
Y1 - 1999/10/4
N2 - The aim of this study is to assess the clinical performance of 6 different low-flux dialysis membranes under steady-state conditions in terms of urea and phosphate clearances. Ten stable hemodialysis patients were examined. The following dialyzers were studied, all in 1.5to 1.6-m2 format: cuprammonium, cellulose acetate, cellulose diacetate, hemophane, polysulfone (low-flux), and polysynthane. The following parameters were examined: urea reduction ratio, phosphate reduction ratio, 'instantaneous dialyzer clearance' for urea and phosphate, and total amount of urea and phosphate removed in the dialysate over a 1-week (three dialyses) period. Although there were differences between the membranes, all produced results within a narrow range. There was no one membrane that produced superior clearances in all categories. The cellulose acetate membrane was the least satisfactory membrane. Phosphate clearances were at best one third that of urea clearances. When choosing a low-flux dialysis membrane, urea and phosphate clearances are so similar amongst different membranes that other criteria are likely to have a greater influence on the choice of membrane.
AB - The aim of this study is to assess the clinical performance of 6 different low-flux dialysis membranes under steady-state conditions in terms of urea and phosphate clearances. Ten stable hemodialysis patients were examined. The following dialyzers were studied, all in 1.5to 1.6-m2 format: cuprammonium, cellulose acetate, cellulose diacetate, hemophane, polysulfone (low-flux), and polysynthane. The following parameters were examined: urea reduction ratio, phosphate reduction ratio, 'instantaneous dialyzer clearance' for urea and phosphate, and total amount of urea and phosphate removed in the dialysate over a 1-week (three dialyses) period. Although there were differences between the membranes, all produced results within a narrow range. There was no one membrane that produced superior clearances in all categories. The cellulose acetate membrane was the least satisfactory membrane. Phosphate clearances were at best one third that of urea clearances. When choosing a low-flux dialysis membrane, urea and phosphate clearances are so similar amongst different membranes that other criteria are likely to have a greater influence on the choice of membrane.
KW - Hemodialysis
KW - Low-flux dialysis membranes
UR - http://www.scopus.com/inward/record.url?scp=0032836619&partnerID=8YFLogxK
U2 - 10.1046/j.1525-1594.1999.06297.x
DO - 10.1046/j.1525-1594.1999.06297.x
M3 - Article
VL - 23
SP - 817
EP - 821
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 9
ER -