TY - JOUR
T1 - Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer screening
T2 - A systematic review and meta-analysis
AU - Dolatkhah, Roya
AU - Dastgiri, Saeed
AU - Jafarabadi, Mohammad Asghari
AU - Abdolahi, Hossein Mashhadi
AU - Somi, Mohammad Hossein
N1 - Funding Information:
The study was approved and supported as a research grant, by Ministry of Health and Medical Education, Deputy of Research and Technology (Grant number: 700/98 , 2015.03.14 [1394/12/24]) from Iran Ministry of Health.
Publisher Copyright:
© 2022 Elsevier España, S.L.U.
PY - 2022/12
Y1 - 2022/12
N2 - Introduction: This study aimed to collect and summarize test data and conduct a meta-analysis, with respect to the Multitarget Stool DNA test sensitivity and specificity, compared to colonoscopy. Material and methods: All manuscripts were screened for eligibility according to inclusion criteria. Participants were a normal population at an average risk of developing CRC. Intervention was Stool based and DNA panel tests compared with colonoscopy, and outcome was detection of CRC and any pre-cancerous lesions. Inter-study and inconsistency (using the I-squared test) were assessed. Results: Meta-analyses of the Mt-sDNA test showed a combined sensitivity of 89%, 51%, and 76% for the detection of CRC, advanced adenoma (AA), and combined CRC and AA, respectively. The overall specificity was 91%, 89%, and 90% for the detection of CRC, AA, and combined CRC and AA, respectively. Conclusion: Mt-sDNA had significantly acceptable diagnostic accuracy for CRC and AA diagnosis, but still has lower sensitivity and specificity than colonoscopy.
AB - Introduction: This study aimed to collect and summarize test data and conduct a meta-analysis, with respect to the Multitarget Stool DNA test sensitivity and specificity, compared to colonoscopy. Material and methods: All manuscripts were screened for eligibility according to inclusion criteria. Participants were a normal population at an average risk of developing CRC. Intervention was Stool based and DNA panel tests compared with colonoscopy, and outcome was detection of CRC and any pre-cancerous lesions. Inter-study and inconsistency (using the I-squared test) were assessed. Results: Meta-analyses of the Mt-sDNA test showed a combined sensitivity of 89%, 51%, and 76% for the detection of CRC, advanced adenoma (AA), and combined CRC and AA, respectively. The overall specificity was 91%, 89%, and 90% for the detection of CRC, AA, and combined CRC and AA, respectively. Conclusion: Mt-sDNA had significantly acceptable diagnostic accuracy for CRC and AA diagnosis, but still has lower sensitivity and specificity than colonoscopy.
KW - Accuracy
KW - Colorectal cancer
KW - Multitarget
KW - Screening
KW - Stool test
UR - http://www.scopus.com/inward/record.url?scp=85124871023&partnerID=8YFLogxK
U2 - 10.1016/j.gastrohep.2022.01.007
DO - 10.1016/j.gastrohep.2022.01.007
M3 - Article
C2 - 35101601
AN - SCOPUS:85124871023
SN - 0210-5705
VL - 45
SP - 753
EP - 766
JO - Gastroenterologia y Hepatologia
JF - Gastroenterologia y Hepatologia
IS - 10
ER -
