Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review

Matthew Francis Chersich, Johanna Takkinen, Caroline Charlier, Alexandre Leclercq, Paul E. Adams, Gauri Godbole, Ursula Altmeyer, Ingrid H.M. Friesema, Lisa Labbé Sandelin, Lorna Jenkin, Luigi Fontana, Raffaella Aldigeri, Francois Venter, Stanley M. F. Luchters, Marc Lecuit, Luca Cimino

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

Original languageEnglish
Pages (from-to)508-517
Number of pages10
JournalOcular Immunology and Inflammation
Volume26
Issue number4
DOIs
Publication statusPublished - 2018

Keywords

  • Endophthalmitis
  • Listeria monocytogenes
  • ocular inflammation
  • systematic review

Cite this

Chersich, M. F., Takkinen, J., Charlier, C., Leclercq, A., Adams, P. E., Godbole, G., ... Cimino, L. (2018). Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review. Ocular Immunology and Inflammation, 26(4), 508-517. https://doi.org/10.1080/09273948.2016.1276788
Chersich, Matthew Francis ; Takkinen, Johanna ; Charlier, Caroline ; Leclercq, Alexandre ; Adams, Paul E. ; Godbole, Gauri ; Altmeyer, Ursula ; Friesema, Ingrid H.M. ; Labbé Sandelin, Lisa ; Jenkin, Lorna ; Fontana, Luigi ; Aldigeri, Raffaella ; Venter, Francois ; Luchters, Stanley M. F. ; Lecuit, Marc ; Cimino, Luca. / Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis : A Systematic Review. In: Ocular Immunology and Inflammation. 2018 ; Vol. 26, No. 4. pp. 508-517.
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title = "Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review",
abstract = "Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57{\%} male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89{\%}). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85{\%}, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.",
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Chersich, MF, Takkinen, J, Charlier, C, Leclercq, A, Adams, PE, Godbole, G, Altmeyer, U, Friesema, IHM, Labbé Sandelin, L, Jenkin, L, Fontana, L, Aldigeri, R, Venter, F, Luchters, SMF, Lecuit, M & Cimino, L 2018, 'Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review' Ocular Immunology and Inflammation, vol. 26, no. 4, pp. 508-517. https://doi.org/10.1080/09273948.2016.1276788

Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis : A Systematic Review. / Chersich, Matthew Francis; Takkinen, Johanna; Charlier, Caroline; Leclercq, Alexandre; Adams, Paul E.; Godbole, Gauri; Altmeyer, Ursula; Friesema, Ingrid H.M.; Labbé Sandelin, Lisa; Jenkin, Lorna; Fontana, Luigi; Aldigeri, Raffaella; Venter, Francois; Luchters, Stanley M. F.; Lecuit, Marc; Cimino, Luca.

In: Ocular Immunology and Inflammation, Vol. 26, No. 4, 2018, p. 508-517.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis

T2 - A Systematic Review

AU - Chersich, Matthew Francis

AU - Takkinen, Johanna

AU - Charlier, Caroline

AU - Leclercq, Alexandre

AU - Adams, Paul E.

AU - Godbole, Gauri

AU - Altmeyer, Ursula

AU - Friesema, Ingrid H.M.

AU - Labbé Sandelin, Lisa

AU - Jenkin, Lorna

AU - Fontana, Luigi

AU - Aldigeri, Raffaella

AU - Venter, Francois

AU - Luchters, Stanley M. F.

AU - Lecuit, Marc

AU - Cimino, Luca

PY - 2018

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N2 - Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

AB - Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis. Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded. Results: Most cases occurred in 2000–2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5–17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes. Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

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