Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Hartmut Döhner, Elihu Estey, David Grimwade, Sergio Amadori, Frederick R. Appelbaum, Thomas Büchner, Hervé Dombret, Benjamin L. Ebert, Pierre Fenaux, Richard A. Larson, Ross L. Levine, Francesco Lo-Coco, Tomoki Naoe, Dietger Niederwieser, Gert J Ossenkoppele, Miguel A. Sanz, Jorge Sierra, Martin S. Tallman, Hwei Fang Tien, Andrew H. Wei & 2 others Bob Löwenberg, Clara D. Bloomfield

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

The first edition of the European Leuke-miaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

Original languageEnglish
Pages (from-to)424-447
Number of pages24
JournalBlood
Volume129
Issue number4
DOIs
Publication statusPublished - 26 Jan 2017

Cite this

Döhner, H., Estey, E., Grimwade, D., Amadori, S., Appelbaum, F. R., Büchner, T., ... Bloomfield, C. D. (2017). Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood, 129(4), 424-447. https://doi.org/10.1182/blood-2016-08-733196
Döhner, Hartmut ; Estey, Elihu ; Grimwade, David ; Amadori, Sergio ; Appelbaum, Frederick R. ; Büchner, Thomas ; Dombret, Hervé ; Ebert, Benjamin L. ; Fenaux, Pierre ; Larson, Richard A. ; Levine, Ross L. ; Lo-Coco, Francesco ; Naoe, Tomoki ; Niederwieser, Dietger ; Ossenkoppele, Gert J ; Sanz, Miguel A. ; Sierra, Jorge ; Tallman, Martin S. ; Tien, Hwei Fang ; Wei, Andrew H. ; Löwenberg, Bob ; Bloomfield, Clara D. / Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel. In: Blood. 2017 ; Vol. 129, No. 4. pp. 424-447.
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title = "Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel",
abstract = "The first edition of the European Leuke-miaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.",
author = "Hartmut D{\"o}hner and Elihu Estey and David Grimwade and Sergio Amadori and Appelbaum, {Frederick R.} and Thomas B{\"u}chner and Herv{\'e} Dombret and Ebert, {Benjamin L.} and Pierre Fenaux and Larson, {Richard A.} and Levine, {Ross L.} and Francesco Lo-Coco and Tomoki Naoe and Dietger Niederwieser and Ossenkoppele, {Gert J} and Sanz, {Miguel A.} and Jorge Sierra and Tallman, {Martin S.} and Tien, {Hwei Fang} and Wei, {Andrew H.} and Bob L{\"o}wenberg and Bloomfield, {Clara D.}",
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Döhner, H, Estey, E, Grimwade, D, Amadori, S, Appelbaum, FR, Büchner, T, Dombret, H, Ebert, BL, Fenaux, P, Larson, RA, Levine, RL, Lo-Coco, F, Naoe, T, Niederwieser, D, Ossenkoppele, GJ, Sanz, MA, Sierra, J, Tallman, MS, Tien, HF, Wei, AH, Löwenberg, B & Bloomfield, CD 2017, 'Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel' Blood, vol. 129, no. 4, pp. 424-447. https://doi.org/10.1182/blood-2016-08-733196

Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel. / Döhner, Hartmut; Estey, Elihu; Grimwade, David; Amadori, Sergio; Appelbaum, Frederick R.; Büchner, Thomas; Dombret, Hervé; Ebert, Benjamin L.; Fenaux, Pierre; Larson, Richard A.; Levine, Ross L.; Lo-Coco, Francesco; Naoe, Tomoki; Niederwieser, Dietger; Ossenkoppele, Gert J; Sanz, Miguel A.; Sierra, Jorge; Tallman, Martin S.; Tien, Hwei Fang; Wei, Andrew H.; Löwenberg, Bob; Bloomfield, Clara D.

In: Blood, Vol. 129, No. 4, 26.01.2017, p. 424-447.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Diagnosis and management of AML in adults

T2 - 2017 ELN recommendations from an international expert panel

AU - Döhner, Hartmut

AU - Estey, Elihu

AU - Grimwade, David

AU - Amadori, Sergio

AU - Appelbaum, Frederick R.

AU - Büchner, Thomas

AU - Dombret, Hervé

AU - Ebert, Benjamin L.

AU - Fenaux, Pierre

AU - Larson, Richard A.

AU - Levine, Ross L.

AU - Lo-Coco, Francesco

AU - Naoe, Tomoki

AU - Niederwieser, Dietger

AU - Ossenkoppele, Gert J

AU - Sanz, Miguel A.

AU - Sierra, Jorge

AU - Tallman, Martin S.

AU - Tien, Hwei Fang

AU - Wei, Andrew H.

AU - Löwenberg, Bob

AU - Bloomfield, Clara D.

PY - 2017/1/26

Y1 - 2017/1/26

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U2 - 10.1182/blood-2016-08-733196

DO - 10.1182/blood-2016-08-733196

M3 - Review Article

VL - 129

SP - 424

EP - 447

JO - Blood

JF - Blood

SN - 0006-4971

IS - 4

ER -

Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood. 2017 Jan 26;129(4):424-447. https://doi.org/10.1182/blood-2016-08-733196