Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Cynthia Soon; Paul Donnelly; Bradley Turner; Lin Hung; Peter Crouch; Nicki Sherratt; Jiang-Li Tan; Nastasia Lim; Linh Lam; Laura Bica; Sin Chun Lim; James Hickey; Julia Morizzi; Andrew Powell; David Finkelstein; Janetta Culvenor; Colin Masters; James Duce; Anthony White; Kevin Barnham; Qiao-Xin Lin

doi:10.1074/jbc.M111.274407

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Cynthia Soon
, Paul Donnelly
, Bradley Turner
, Lin Hung
, Peter Crouch
, Nicki Sherratt
, Jiang-Li Tan
, Nastasia Lim
, Linh Lam
, Laura Bica
, Sin Chun Lim
, James Hickey
, Julia Morizzi
, Andrew Powell
, David Finkelstein
, Janetta Culvenor
, Colin Masters
, James Duce
, Anthony White
, Kevin Barnham

Qiao-Xin Lin

Centre for Drug Candidate Optimisation

Research output: Contribution to journal › Article › Research › peer-review

135 Citations (Scopus)

Abstract

Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.

Original language	English
Pages (from-to)	44035 - 44044
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	286
Issue number	51
DOIs	https://doi.org/10.1074/jbc.M111.274407
Publication status	Published - 2011

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10.1074/jbc.M111.274407

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Soon, C., Donnelly, P., Turner, B., Hung, L., Crouch, P., Sherratt, N., Tan, J.-L., Lim, N., Lam, L., Bica, L., Lim, S. C., Hickey, J., Morizzi, J., Powell, A., Finkelstein, D., Culvenor, J., Masters, C., Duce, J., White, A., ... Lin, Q.-X. (2011). Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model. Journal of Biological Chemistry, 286(51), 44035 - 44044. https://doi.org/10.1074/jbc.M111.274407

@article{0a9bd328136f4b89806f5df23f07049a,

title = "Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model",

abstract = "Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.",

author = "Cynthia Soon and Paul Donnelly and Bradley Turner and Lin Hung and Peter Crouch and Nicki Sherratt and Jiang-Li Tan and Nastasia Lim and Linh Lam and Laura Bica and Lim, \{Sin Chun\} and James Hickey and Julia Morizzi and Andrew Powell and David Finkelstein and Janetta Culvenor and Colin Masters and James Duce and Anthony White and Kevin Barnham and Qiao-Xin Lin",

year = "2011",

doi = "10.1074/jbc.M111.274407",

language = "English",

volume = "286",

pages = "44035 -- 44044",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology",

number = "51",

}

Soon, C, Donnelly, P, Turner, B, Hung, L, Crouch, P, Sherratt, N, Tan, J-L, Lim, N, Lam, L, Bica, L, Lim, SC, Hickey, J, Morizzi, J, Powell, A, Finkelstein, D, Culvenor, J, Masters, C, Duce, J, White, A, Barnham, K & Lin, Q-X 2011, 'Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model', Journal of Biological Chemistry, vol. 286, no. 51, pp. 44035 - 44044. https://doi.org/10.1074/jbc.M111.274407

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model. / Soon, Cynthia; Donnelly, Paul; Turner, Bradley et al.
In: Journal of Biological Chemistry, Vol. 286, No. 51, 2011, p. 44035 - 44044.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

AU - Soon, Cynthia

AU - Donnelly, Paul

AU - Turner, Bradley

AU - Hung, Lin

AU - Crouch, Peter

AU - Sherratt, Nicki

AU - Tan, Jiang-Li

AU - Lim, Nastasia

AU - Lam, Linh

AU - Bica, Laura

AU - Lim, Sin Chun

AU - Hickey, James

AU - Morizzi, Julia

AU - Powell, Andrew

AU - Finkelstein, David

AU - Culvenor, Janetta

AU - Masters, Colin

AU - Duce, James

AU - White, Anthony

AU - Barnham, Kevin

AU - Lin, Qiao-Xin

PY - 2011

Y1 - 2011

N2 - Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.

AB - Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.

UR - http://www.jbc.org/content/286/51/44035.full.pdf+html

U2 - 10.1074/jbc.M111.274407

DO - 10.1074/jbc.M111.274407

M3 - Article

SN - 0021-9258

VL - 286

SP - 44035

EP - 44044

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 51

ER -

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Abstract

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