Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Cynthia Soon, Paul Donnelly, Bradley Turner, Lin Hung, Peter Crouch, Nicki Sherratt, Jiang-Li Tan, Nastasia Lim, Linh Lam, Laura Bica, Sin Chun Lim, James Hickey, Julia Morizzi, Andrew Powell, David Finkelstein, Janetta Culvenor, Colin Masters, James Duce, Anthony White, Kevin BarnhamQiao-Xin Lin

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Abstract

Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.
Original languageEnglish
Pages (from-to)44035 - 44044
Number of pages10
JournalThe Journal of Biological Chemistry
Volume286
Issue number51
DOIs
Publication statusPublished - 2011

Cite this

Soon, C., Donnelly, P., Turner, B., Hung, L., Crouch, P., Sherratt, N., Tan, J-L., Lim, N., Lam, L., Bica, L., Lim, S. C., Hickey, J., Morizzi, J., Powell, A., Finkelstein, D., Culvenor, J., Masters, C., Duce, J., White, A., ... Lin, Q-X. (2011). Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model. The Journal of Biological Chemistry, 286(51), 44035 - 44044. https://doi.org/10.1074/jbc.M111.274407