Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII (atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Cynthia Soon, Paul Donnelly, Bradley Turner, Lin Hung, Peter Crouch, Nicki Sherratt, Jiang-Li Tan, Nastasia Lim, Linh Lam, Laura Bica, Sin Chun Lim, James Hickey, Julia Morizzi, Andrew Powell, David Finkelstein, Janetta Culvenor, Colin Masters, James Duce, Anthony White, Kevin BarnhamQiao-Xin Lin

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Abstract

Background: CuII(atsm) [(diacetylbis(N(4)-methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1G93A mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte, and microglial activation also resulted from treatment. Conclusion: CuII(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.
Original languageEnglish
Pages (from-to)44035 - 44044
Number of pages10
JournalJournal of Biological Chemistry
Volume286
Issue number51
DOIs
Publication statusPublished - 2011

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