Diabetic vascular hypertrophy and albuminuria: Effect of angiotensin converting enzyme inhibition

Terri J. Allen, U. Lennart Hulthen, Jonathan R. Rumble, Mariusz Jasik, Mark E. Cooper

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Abstract

The role of angiotensin-converting enzyme (ACE) inhibition with ramipril on mesenteric vascular hypertrophy and urinary albumin excretion was explored in a normotensive model of experimental diabetes. Serial measurements of albuminuria were performed in Sprague-Dawley control, diabetic rats, and diabetic rats treated with ramipril. Over 24 weeks, urinary albumin excretion showed a continuous rise in the untreated diabetic rats. Ramipril prevented the increase in albuminuria over the whole study period. After 6 months, animals were perfused with glutaraldehyde and sacrificed for measurement of mesenteric vessel wall/lumen ratio and kidney weight. Diabetes was associated with increased mesenteric wall/lumen ratio and kidney weight. ACE inhibition, despite no effect on glycemic control, attenuated mesenteric vascular hypertrophy but did not decrease kidney weight. In addition to the well-described renoprotective effects of ACE inhibition in diabetes, this class of agents may have a favorable effect on diabetic vascular disease.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalJournal of Diabetes and its Complications
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

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