Diabetic vascular complications

Mark E. Cooper, Richard E. Gilbert, George Jerums

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49 Citations (Scopus)

Abstract

1. Diabetic vascular complications can be arbitrarily divided into micro- and macrovascular complications, the major microvascular complications being nephropathy, retinopathy and neuropathy. Macrovascular complications are due to accelerated atherosclerosis and include ischaemic heart disease, cerebrovascular disease and peripheral vascular disease. 2. It is postulated that metabolic and haemodynamic factors interact leading to the development of diabetic vascular complications. 3. Advanced glycation appears to be an important pathway in the pathogenesis of diabetic complications with evidence that the inhibitor of this process, aminoguanidine, attenuates the development of a range of diabetic vascular complications. 4. The results of experimental studies have led to large-scale clinical trials of various therapeutic agents that act to interfere with the metabolic and haemodynamic pathways implicated in the progression of diabetic complications.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume24
Issue number9-10
DOIs
Publication statusPublished - 1 Jan 1997
Externally publishedYes

Keywords

  • Aminoguanidine
  • Diabetes
  • Glycation
  • Hypertension
  • Nephropathy
  • Retinopathy
  • Vasculopathy

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