Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Jasmin Chendi Li; Anida Velagic; Cheng Xue Qin; Mandy Li; Chen Huei Leo; Barbara K. Kemp-Harper; Rebecca H. Ritchie; Owen L. Woodman

doi:10.3389/fphar.2020.585740

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Jasmin Chendi Li, Anida Velagic, Cheng Xue Qin, Mandy Li, Chen Huei Leo, Barbara K. Kemp-Harper, Rebecca H. Ritchie, Owen L. Woodman

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown.

Original language	English
Article number	585740
Number of pages	16
Journal	Frontiers in Pharmacology
Volume	11
DOIs	https://doi.org/10.3389/fphar.2020.585740
Publication status	Published - 21 Jan 2021

Keywords

carotid arteries, nitroxyl mediated relaxation in diabetes
Diabetes
endothelium
nitric oxide
nitroxyl

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fphar.2020.585740Licence: CC BY

Cite this

@article{d06859b4602241d98607faa9c6d9eb45,

title = "Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries",

abstract = "Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown.",

keywords = "carotid arteries, nitroxyl mediated relaxation in diabetes, Diabetes, endothelium, nitric oxide, nitroxyl",

author = "Li, {Jasmin Chendi} and Anida Velagic and Qin, {Cheng Xue} and Mandy Li and Leo, {Chen Huei} and Kemp-Harper, {Barbara K.} and Ritchie, {Rebecca H.} and Woodman, {Owen L.}",

year = "2021",

month = jan,

day = "21",

doi = "10.3389/fphar.2020.585740",

language = "English",

volume = "11",

journal = "Frontiers in Pharmacology",

issn = "1663-9812",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

AU - Li, Jasmin Chendi

AU - Velagic, Anida

AU - Qin, Cheng Xue

AU - Li, Mandy

AU - Leo, Chen Huei

AU - Kemp-Harper, Barbara K.

AU - Ritchie, Rebecca H.

AU - Woodman, Owen L.

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown.

AB - Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown.

KW - carotid arteries, nitroxyl mediated relaxation in diabetes

KW - Diabetes

KW - endothelium

KW - nitric oxide

KW - nitroxyl

UR - http://www.scopus.com/inward/record.url?scp=85100573172&partnerID=8YFLogxK

U2 - 10.3389/fphar.2020.585740

DO - 10.3389/fphar.2020.585740

M3 - Article

AN - SCOPUS:85100573172

SN - 1663-9812

VL - 11

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 585740

ER -

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Research Fellowship: Protecting how the heart functions in health and disease

Therapeutic Approaches to Circumvent NO• Resistance in the Type 2 Diabetic Heart and Vasculature

Cite this

Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Research Fellowship: Protecting how the heart functions in health and disease

Therapeutic Approaches to Circumvent NO• Resistance in the Type 2 Diabetic Heart and Vasculature

Cite this