Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries

Jasmin Chendi Li, Anida Velagic, Cheng Xue Qin, Mandy Li, Chen Huei Leo, Barbara K. Kemp-Harper, Rebecca H. Ritchie, Owen L. Woodman

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Abstract

Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown.

Original languageEnglish
Article number585740
Number of pages16
JournalFrontiers in Pharmacology
Volume11
DOIs
Publication statusPublished - 21 Jan 2021

Keywords

  • carotid arteries, nitroxyl mediated relaxation in diabetes
  • Diabetes
  • endothelium
  • nitric oxide
  • nitroxyl

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