Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial

Michael C Reade; Kim O'Sullivan; Samantha Bates; Donna Goldsmith; William R S T J Ainslie; Rinaldo Bellomo

doi:10.1186/cc7890

Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial

Michael C Reade, Kim O'Sullivan, Samantha Bates, Donna Goldsmith, William R S T J Ainslie, Rinaldo Bellomo

Research output: Contribution to journal › Article › Research › peer-review

185 Citations (Scopus)

Abstract

Agitated delirium is common in patients undergoing mechanical ventilation, and is often treated with haloperidol despite concerns about safety and efficacy. Use of conventional sedatives to control agitation can preclude extubation. Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation.

Original language	English
Pages (from-to)	1 - 10
Number of pages	10
Journal	Critical Care
Volume	13
Issue number	3 (Art.No.: R75)
DOIs	https://doi.org/10.1186/cc7890
Publication status	Published - 2009
Externally published	Yes

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10.1186/cc7890

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Cite this

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title = "Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial",

abstract = "Agitated delirium is common in patients undergoing mechanical ventilation, and is often treated with haloperidol despite concerns about safety and efficacy. Use of conventional sedatives to control agitation can preclude extubation. Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation.",

author = "Reade, {Michael C} and Kim O'Sullivan and Samantha Bates and Donna Goldsmith and Ainslie, {William R S T J} and Rinaldo Bellomo",

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Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. / Reade, Michael C; O'Sullivan, Kim; Bates, Samantha; Goldsmith, Donna; Ainslie, William R S T J; Bellomo, Rinaldo.

In: Critical Care, Vol. 13, No. 3 (Art.No.: R75), 2009, p. 1 - 10.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial

AU - Reade, Michael C

AU - O'Sullivan, Kim

AU - Bates, Samantha

AU - Goldsmith, Donna

AU - Ainslie, William R S T J

AU - Bellomo, Rinaldo

PY - 2009

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N2 - Agitated delirium is common in patients undergoing mechanical ventilation, and is often treated with haloperidol despite concerns about safety and efficacy. Use of conventional sedatives to control agitation can preclude extubation. Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation.

AB - Agitated delirium is common in patients undergoing mechanical ventilation, and is often treated with haloperidol despite concerns about safety and efficacy. Use of conventional sedatives to control agitation can preclude extubation. Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717438/

U2 - 10.1186/cc7890

DO - 10.1186/cc7890

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VL - 13

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JO - Critical Care

JF - Critical Care

SN - 1364-8535

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