Development of the kidney: Morphology and mechanisms

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Abstract

The development of the mammalian kidney has been extensively studied for the past 60 to 70 years, and our understanding of renal development and molecular regulation is perhaps better understood than that of any other organ. This chapter provides an overview of the development of the three mammalian excretory organs (pronephroi, mesonephroi, and metanephroi) but explores metanephric development in detail. The processes of ureteric budding, ureteric branching morphogenesis, and nephrogenesis are also described in detail, as is our current understanding of the nature and roles of renal progenitor cells. In addition, the roles of the renal stroma in kidney development are considered, and renal vascular development is described. Finally, the effects of preterm birth on kidney development are addressed.
Original languageEnglish
Title of host publicationFetal and Neonatal Physiology
EditorsRichard A. Polin, Steven H. Abman, David H. Rowitch, William E. Benitz, William W. Fox
Place of PublicationPhiladelphia, PA
PublisherElsevier
Pages953-964.e4
Number of pages16
Volume2
Edition5th
ISBN (Print)9780323352147
DOIs
Publication statusPublished - 2017

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