Development of the cerebral cortex and the effect of the intrauterine environment

Sebastian Quezada, Margie Castillo-Melendez, David W. Walker, Mary Tolcos

Research output: Contribution to journalReview ArticleOtherpeer-review

15 Citations (Scopus)


The human brain is one of the most complex structures currently under study. Its external shape is highly convoluted, with folds and valleys over the entire surface of the cortex. Disruption of the normal pattern of folding is associated with a number of abnormal neurological outcomes, some serious for the individual. Most of our knowledge of the normal development and folding of the cerebral cortex (gyrification) focuses on the internal, biological (i.e. genetically driven) mechanisms of the brain that drive gyrification. However, the impact of an adverse intrauterine and maternal physiological environment on cortical folding during fetal development has been understudied. Accumulating evidence suggests that the state of the intrauterine and maternal environment can have a significant impact on gyrification of the fetal cerebral cortex. This review summarises our current knowledge of how development in a suboptimal intrauterine and maternal environment can affect the normal development of the folded cerebral cortex.

Original languageEnglish
Pages (from-to)5665-5674
Number of pages10
JournalThe Journal of Physiology
Issue number23
Publication statusPublished - 1 Dec 2018


  • brain development
  • gyrification
  • intrauterine growth restriction

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