Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Brad Sleebs; Danny Ganame; Alla Levit; Ian Street; Alison Gregg; Hendrik Falk; Jonathan Baell

doi:10.1039/C1MD00138H

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Brad Sleebs, Danny Ganame, Alla Levit, Ian Street, Alison Gregg, Hendrik Falk, Jonathan Baell

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

The LIMK family of proteins are serine protein kinases comprised of two proteins, LIMK1 and LIMK2 (LIMK stands for LIM-kinase, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3). They are recognised by two common LIM domains, along with a PDZ motif and a catalytic domain. LIMK 1 and 2 overall share approximately 50 homology, with 70 identity in the catalytic domain.

Original language	English
Pages (from-to)	982 - 986
Number of pages	5
Journal	MedChemComm
Volume	2
DOIs	https://doi.org/10.1039/C1MD00138H
Publication status	Published - 2011

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title = "Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors",

abstract = "The LIMK family of proteins are serine protein kinases comprised of two proteins, LIMK1 and LIMK2 (LIMK stands for LIM-kinase, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3). They are recognised by two common LIM domains, along with a PDZ motif and a catalytic domain. LIMK 1 and 2 overall share approximately 50 homology, with 70 identity in the catalytic domain.",

author = "Brad Sleebs and Danny Ganame and Alla Levit and Ian Street and Alison Gregg and Hendrik Falk and Jonathan Baell",

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T1 - Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

AU - Sleebs, Brad

AU - Ganame, Danny

AU - Levit, Alla

AU - Street, Ian

AU - Gregg, Alison

AU - Falk, Hendrik

AU - Baell, Jonathan

PY - 2011

Y1 - 2011

N2 - The LIMK family of proteins are serine protein kinases comprised of two proteins, LIMK1 and LIMK2 (LIMK stands for LIM-kinase, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3). They are recognised by two common LIM domains, along with a PDZ motif and a catalytic domain. LIMK 1 and 2 overall share approximately 50 homology, with 70 identity in the catalytic domain.

AB - The LIMK family of proteins are serine protein kinases comprised of two proteins, LIMK1 and LIMK2 (LIMK stands for LIM-kinase, where LIM is an acronym of the three gene products Lin-11, Isl-1 and Mec-3). They are recognised by two common LIM domains, along with a PDZ motif and a catalytic domain. LIMK 1 and 2 overall share approximately 50 homology, with 70 identity in the catalytic domain.

UR - http://pubs.rsc.org/en/content/articlelanding/2011/md/c1md00138h

U2 - 10.1039/C1MD00138H

DO - 10.1039/C1MD00138H

M3 - Article

SN - 2040-2503

VL - 2

SP - 982

EP - 986

JO - MedChemComm

JF - MedChemComm

ER -

Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

Abstract

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