Development of function in the fetus

Karen M. Moritz, Marelyn Wintour-Coghlan, M. Jane Black, John F. Bertram, Georgina Caruana

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The mesonephros is the functional adult kidney in amphibia and fish and is an essential precursor for the formation of the metanephros. Thus, gene defects which prevent formation of a mesonephros inevitably result in total anephric neonates. The transient mesonephros consists, generally, of a small number of nephrons (30-70) which contain a glomerulus, proximal and distal tubules, but no loop of Henle (Moritz and Wintour 1999; Ludwig and Landman 2005; Wrobel 2001). In some species, the collecting duct drains via the cloaca and urachus, into the allantoic compartment. In those species in which the placenta is cotyledonary (sheep, cattle) or diffuse (pig), the accumulation of allantoic fluid allows the growth of the allantoic membrane to reach the whole uterine surface, including caruncles (the predetermined site of placenta formation) in both horns of the uterus. However, the allantois can also reabsorb fluid. Fetal vascularization of the placenta is carried via the allantois. In many species, there is unequivocal evidence that the mesonephros functions both as an excretory organ (sheep, pig, rabbit) and as a source of circulating hormones and enzymes (erythropoietin, renin) and contains receptors for glucocorticoids, mineralocorticoids and growth factors such as insulin and IGF-1 (Peers et al. 2001; Kitraki et al. 1997; Leeson 1959; Korgun et al. 2003) as well as Ang II receptors (Butkus et al. 1997). In addition, the mesonephros has been shown to contribute cells to the developing gonads, and the aorta-gonad-mesonephric (AGM) region is a source of haemopoietic stem cells (Sainio and Raatikainen 1999). The glucocorticoid receptors found in the sheep were shown to be functional because a 48-h exposure of the developing fetus, at a time when only mesonephros was present (26-28 days), produced a significant alteration in allantoic fluid composition (Peers et al. 2001).

Original languageEnglish
Title of host publicationFactors Influencing Mammalian Kidney Development
Subtitle of host publicationImplications for Health in Adult Life
Pages27-32
Number of pages6
DOIs
Publication statusPublished - 3 Jun 2008

Publication series

NameAdvances in Anatomy Embryology and Cell Biology
Volume196
ISSN (Print)0301-5556

Cite this

Moritz, K. M., Wintour-Coghlan, M., Black, M. J., Bertram, J. F., & Caruana, G. (2008). Development of function in the fetus. In Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life (pp. 27-32). (Advances in Anatomy Embryology and Cell Biology; Vol. 196). https://doi.org/10.1007/978-3-540-77768-7_6
Moritz, Karen M. ; Wintour-Coghlan, Marelyn ; Black, M. Jane ; Bertram, John F. ; Caruana, Georgina. / Development of function in the fetus. Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. pp. 27-32 (Advances in Anatomy Embryology and Cell Biology).
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Moritz, KM, Wintour-Coghlan, M, Black, MJ, Bertram, JF & Caruana, G 2008, Development of function in the fetus. in Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. Advances in Anatomy Embryology and Cell Biology, vol. 196, pp. 27-32. https://doi.org/10.1007/978-3-540-77768-7_6

Development of function in the fetus. / Moritz, Karen M.; Wintour-Coghlan, Marelyn; Black, M. Jane; Bertram, John F.; Caruana, Georgina.

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. p. 27-32 (Advances in Anatomy Embryology and Cell Biology; Vol. 196).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AB - The mesonephros is the functional adult kidney in amphibia and fish and is an essential precursor for the formation of the metanephros. Thus, gene defects which prevent formation of a mesonephros inevitably result in total anephric neonates. The transient mesonephros consists, generally, of a small number of nephrons (30-70) which contain a glomerulus, proximal and distal tubules, but no loop of Henle (Moritz and Wintour 1999; Ludwig and Landman 2005; Wrobel 2001). In some species, the collecting duct drains via the cloaca and urachus, into the allantoic compartment. In those species in which the placenta is cotyledonary (sheep, cattle) or diffuse (pig), the accumulation of allantoic fluid allows the growth of the allantoic membrane to reach the whole uterine surface, including caruncles (the predetermined site of placenta formation) in both horns of the uterus. However, the allantois can also reabsorb fluid. Fetal vascularization of the placenta is carried via the allantois. In many species, there is unequivocal evidence that the mesonephros functions both as an excretory organ (sheep, pig, rabbit) and as a source of circulating hormones and enzymes (erythropoietin, renin) and contains receptors for glucocorticoids, mineralocorticoids and growth factors such as insulin and IGF-1 (Peers et al. 2001; Kitraki et al. 1997; Leeson 1959; Korgun et al. 2003) as well as Ang II receptors (Butkus et al. 1997). In addition, the mesonephros has been shown to contribute cells to the developing gonads, and the aorta-gonad-mesonephric (AGM) region is a source of haemopoietic stem cells (Sainio and Raatikainen 1999). The glucocorticoid receptors found in the sheep were shown to be functional because a 48-h exposure of the developing fetus, at a time when only mesonephros was present (26-28 days), produced a significant alteration in allantoic fluid composition (Peers et al. 2001).

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Moritz KM, Wintour-Coghlan M, Black MJ, Bertram JF, Caruana G. Development of function in the fetus. In Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life. 2008. p. 27-32. (Advances in Anatomy Embryology and Cell Biology). https://doi.org/10.1007/978-3-540-77768-7_6