Development of dirhodium(II)-catalyzed generation and enantioselective 1,3-dipolar cycloaddition of carbonyl ylides

David M. Hodgson, Paul A. Stupple, Françoise Y.T.M. Pierard, Agnès H. Labande, Craig Johnstone

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Abstract

Catalytic, enantioselective, tandem carbonyl ylide formation/cycloaddition of 2-diazo-3,6-diketoester 2 with the use of dirhodium tetrakiscarboxylate and tetrakisbinaphtholphosphate catalysts to give the cycloadducts 3 in good yields and up to 90% ee is described.

Original languageEnglish
Pages (from-to)4465-4476
Number of pages12
JournalChemistry - A European Journal
Volume7
Issue number20
DOIs
Publication statusPublished - 15 Oct 2001
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Catalysts
  • Cycloaddition
  • Diazo compounds
  • Rhodium

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