Development of a wireless intra-ocular pressure monitoring system for incorporation into a therapeutic glaucoma drainage implant

Tarun Kakaday, Malcolm Plunkett, Steven McInnes, Jim S Jimmy Li, Nicolas H. Voelcker, Jamie E. Craig

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

1 Citation (Scopus)

Abstract

Glaucoma is a common cause of blindness. Wireless, continuous monitoring of intraocular pressure (IOP) is an important, unsolved goal in managing glaucoma. An IOP monitoring system incorporated into a glaucoma drainage implant (GDI) overcomes the design complexity associated with incorporating a similar system in a more confined space within the eye. The device consists of a micro-electro-mechanical systems (MEMS) based capacitive pressure sensor integrated with an inductor printed directly onto a polyimide printed circuit board (PCB). The device is designed to be incorporated onto the external plate of a therapeutic GDI. The resonance frequency changes as a function of IOP, and is tracked remotely using a spectrum analyzer. A theoretical model for the reader antenna was developed to enable maximal inductive coupling with the IOP sensor implant. Pressure chamber tests indicate that the sensor implant has adequate sensitivity in the IOP range with excellent reproducibility over time. Additionally, we show that sensor sensitivity does not change significantly after encapsulation with polydimethylsiloxane (PDMS) to protect the device from fluid environment. In vitro experiments showed that the signal measured wirelessly through sheep corneal and scleral tissue was adequate indicating potential for using the system in human subjects.

Original languageEnglish
Title of host publicationBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems
DOIs
Publication statusPublished - 19 Jun 2009
Externally publishedYes
EventBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems - RMIT, Melbourne Australia, Melbourne, VIC, Australia
Duration: 10 Dec 200812 Dec 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7270
ISSN (Print)1605-7422

Conference

ConferenceBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems
CountryAustralia
CityMelbourne, VIC
Period10/12/0812/12/08

Keywords

  • Capacitive pressure sensors
  • Glaucoma
  • Glaucoma drainage implant (GDI)
  • Intraocular pressure (IOP)
  • Micro-electro-mechanical systems (MEMS)
  • Printed circuit boards (PCB's)
  • Reader antenna

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