TY - JOUR
T1 - Development of a standardized set of patient-centered outcomes for advanced prostate cancer: An international effort for a unified approach
AU - Morgans, Alicia K
AU - Van Bommel, Annelotte C M
AU - Stowell, Caleb
AU - Abrahm, Janet L
AU - Basch, Ethan
AU - Bekelman, Justin E
AU - Berry, Donna L
AU - Bossi, Alberto
AU - Davis, Ian
AU - de Reijke, Theo M
AU - Denis, Louis Jen
AU - Evans, Susan Margaret
AU - Fleshner, Neil E
AU - George, Daniel J
AU - Kiefert, James J
AU - Lin, Daniel W
AU - Matthew, Andrew G
AU - McDermott, Ray
AU - Payne, Heather
AU - Roos, Ian A G
AU - Schrag, Deborah
AU - Steuber, Thomas
AU - Tombal, Bernard
AU - van Basten, Jean-Paul
AU - van der Hoeven, Jacobus J M
AU - Penson, David F
PY - 2015
Y1 - 2015
N2 - Background There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. Objective We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. Design, setting, and participants The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. Outcome measurements and statistical analysis We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. Results and limitations The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. Conclusions The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Patient summary Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer.
AB - Background There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. Objective We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. Design, setting, and participants The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. Outcome measurements and statistical analysis We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. Results and limitations The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. Conclusions The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Patient summary Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer.
UR - http://goo.gl/W3Jn1k
U2 - 10.1016/j.eururo.2015.06.007
DO - 10.1016/j.eururo.2015.06.007
M3 - Article
SN - 0302-2838
VL - 68
SP - 891
EP - 898
JO - European Urology
JF - European Urology
IS - 5
ER -
