TY - JOUR
T1 - Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging
AU - Ge, Song
AU - Shi, Xiangyang
AU - Baker, James R.
AU - Banaszak Holl, Mark M.
AU - Orr, Bradford G.
PY - 2009/11/17
Y1 - 2009/11/17
N2 - We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O 3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ∼1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.
AB - We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O 3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ∼1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.
UR - http://www.scopus.com/inward/record.url?scp=67650751354&partnerID=8YFLogxK
U2 - 10.1088/0031-9155/54/10/N01
DO - 10.1088/0031-9155/54/10/N01
M3 - Article
C2 - 19398816
AN - SCOPUS:67650751354
SN - 0031-9155
VL - 54
JO - Physics in Medicine & Biology
JF - Physics in Medicine & Biology
IS - 10
ER -