Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging

Song Ge, Xiangyang Shi, James R. Baker, Mark M. Banaszak Holl, Bradford G. Orr

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20 Citations (Scopus)

Abstract

We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O 3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ∼1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.

Original languageEnglish
JournalPhysics in Medicine & Biology
Volume54
Issue number10
DOIs
Publication statusPublished - 17 Nov 2009
Externally publishedYes

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