Development of a microfluidic device system using adhesive vinyl template to produce calcium alginate microbeads for microencapsulation of cells

Chin Fhong Soon, Hiung Yin Yap, Mohd Khairul Ahmad, Kian Sek Tee, Siew Hwa Gan

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

2 Citations (Scopus)

Abstract

Microfabrication technique based on microelectronic technology is commonly used to produce microfluidic devices but this technique involves with costly and toxic chemicals. In this paper, we proposed the use of patterned adhesive vinyl template to produce a poly-dimethylsiloxane (PDMS) microfluidic device that was applied to generate microbeads of calcium alginate for microencapsulation of cells. In the microfluidic system, an infusion pump of high flow rate (2000 µl/min) and a commercial syringe pump were used to emulsify the continuous and disperse phases of liquids in forming the microbeads. Microbeads of calcium alginate in the range of 438 ± 38-799 ± 20 µm were successfully produced using this environmental friendly technique.

Original languageEnglish
Title of host publicationRecent Global Research and Education: Technological Challenges
Subtitle of host publicationProceedings of the 15th International Conference on Global Research and Education Inter-Academia 2016
EditorsRyszard Jabłoński, Roman Szewczyk
Place of PublicationCham Switzerland
PublisherSpringer-Verlag London Ltd.
Pages477-482
Number of pages6
Volume519
ISBN (Electronic)9783319464909
ISBN (Print)9783319464893
DOIs
Publication statusPublished - 2017
Externally publishedYes
Event15th International Conference on Global Research and Education, INTER-ACADEMIA 2016 - Warsaw, Poland
Duration: 26 Sep 201628 Sep 2016

Publication series

NameAdvances in Intelligent Systems and Computing
PublisherSpringer International Publishing
Volume519
ISSN (Print)2194-5357
ISSN (Electronic)2194-5365

Conference

Conference15th International Conference on Global Research and Education, INTER-ACADEMIA 2016
CountryPoland
CityWarsaw
Period26/09/1628/09/16

Keywords

  • Calcium alginate
  • Infusion system
  • Microbeads
  • Microfluidic
  • Vinyl adhesive template

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