The aim of this study is to identify and review literature that presented information about development and application of pharmacoinformatics in pharmaceutical and health sciences. The quality assessment tool for quantitative studies suggested by Cochrane Collaboration was adopted in this review. Independent assessment was conducted to evaluate the quality of the included studies. A databases used for this study and review was PubMed and Science Direct. Both databases search was conducted using the English key words, pharmacoinformatics , pharmacy informatics , medical informatics , health informatics and etc. The search strategy resulted in the inclusion of sources, the majority of which expert opinion and examines the pharmacoinformatics relevance from a theoretical point of view (PubMed, n=72). Based from the keyword of informatics and pharmacy on PubMed databases using advanced search, 59 articles was obtained with particular fields which is title and abstract. The articles are then being filtered by article type, publication dates and languages of articles. The article type which is clinical trial (n=2) and in review articles (n=7). The articles has the range of publication dates which is 10 years (n=34) and 15 years (n=72). The rapid development of internet has led to the pharmacoinformatics technologies to assist the pharmaceutical care and health-related outcomes. Based on the study, it can be concluded that pharmacoinformatics has a lot of advantages and uses especially in pharmaceutical and health sciences.