Development and function of Foxp3+ regulatory T cells

Yuan Min Wang, Joanna Ghali, Geoff Yu Zhang, Min Hu, Ya Wang, Andrew Sawyer, Jimmy Jianheng Zhou, Dhanushka A. Hapudeniya, Yiping Wang, Qi Cao, Guoping Zheng, David C. Harris, Stephen I Alexander

Research output: Contribution to journalReview ArticleOtherpeer-review

23 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalNephrology
Volume21
Issue number2
DOIs
Publication statusPublished - 1 Feb 2016

Keywords

  • autoimmunity
  • Foxp3
  • Tregs

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