Development and function of Foxp3+ regulatory T cells

Yuan Min Wang; Joanna Ghali; Geoff Yu Zhang; Min Hu; Ya Wang; Andrew Sawyer; Jimmy Jianheng Zhou; Dhanushka A. Hapudeniya; Yiping Wang; Qi Cao; Guoping Zheng; David C. Harris; Stephen I Alexander

doi:10.1111/nep.12652

Development and function of Foxp3⁺ regulatory T cells

Yuan Min Wang, Joanna Ghali, Geoff Yu Zhang, Min Hu, Ya Wang, Andrew Sawyer, Jimmy Jianheng Zhou, Dhanushka A. Hapudeniya, Yiping Wang, Qi Cao, Guoping Zheng, David C. Harris, Stephen I Alexander

Centre for Inflammatory Disease Monash Health

Research output: Contribution to journal › Review Article › Other › peer-review

26 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

Original language	English
Pages (from-to)	81-85
Number of pages	5
Journal	Nephrology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1111/nep.12652
Publication status	Published - 1 Feb 2016

Keywords

autoimmunity
Foxp3
Tregs

Access to Document

10.1111/nep.12652

Cite this

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title = "Development and function of Foxp3+ regulatory T cells",

abstract = "Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.",

keywords = "autoimmunity, Foxp3, Tregs",

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AU - Wang, Yuan Min

AU - Ghali, Joanna

AU - Zhang, Geoff Yu

AU - Hu, Min

AU - Wang, Ya

AU - Sawyer, Andrew

AU - Zhou, Jimmy Jianheng

AU - Hapudeniya, Dhanushka A.

AU - Wang, Yiping

AU - Cao, Qi

AU - Zheng, Guoping

AU - Harris, David C.

AU - Alexander, Stephen I

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

AB - Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

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KW - Foxp3

KW - Tregs

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DO - 10.1111/nep.12652

M3 - Review Article

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AN - SCOPUS:84955608746

SN - 1320-5358

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