TY - JOUR
T1 - Development and characterization of gentamicin-loaded arabinoxylan-sodium alginate films as antibacterial wound dressing
AU - Alzarea, Abdulaziz I.
AU - Alruwaili, Nabil K.
AU - Ahmad, Muhammad Masood
AU - Munir, Muhammad Usman
AU - Butt, Adeel Masood
AU - Alrowaili, Ziyad A.
AU - Shahari, Muhammad Syafiq Bin
AU - Almalki, Ziyad S.
AU - Alqahtani, Saad S.
AU - Dolzhenko, Anton V.
AU - Ahmad, Naveed
N1 - Funding Information:
Funding: This research was funded by Deanship of Scientific Research at Jouf University through grant number 40/267. The APC was funded by Jouf University, Saudi Arabia.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Biopolymer-based antibacterial films are attractive materials for wound dressing application because they possess chemical, mechanical, exudate absorption, drug delivery, antibacterial, and biocompatible properties required to support wound healing. Herein, we fabricated and character-ized films composed of arabinoxylan (AX) and sodium alginate (SA) loaded with gentamicin sulfate (GS) for application as a wound dressing. The FTIR, XRD, and thermal analyses show that AX, SA, and GS interacted through hydrogen bonding and were thermally stable. The AXSA film displays desirable wound dressing characteristics: transparency, uniform thickness, smooth surface mor-phology, tensile strength similar to human skin, mild water/exudate uptake capacity, water transmission rate suitable for wound dressing, and excellent cytocompatibility. In Franz diffusion release studies, >80% GS was released from AXSA films in two phases in 24 h following the Fickian diffusion mechanism. In disk diffusion assay, the AXSA films demonstrated excellent antibacterial effect against E.coli, S. aureus, and P. aeruginosa. Overall, the findings suggest that GS-loaded AXSA films hold potential for further development as antibacterial wound dressing material.
AB - Biopolymer-based antibacterial films are attractive materials for wound dressing application because they possess chemical, mechanical, exudate absorption, drug delivery, antibacterial, and biocompatible properties required to support wound healing. Herein, we fabricated and character-ized films composed of arabinoxylan (AX) and sodium alginate (SA) loaded with gentamicin sulfate (GS) for application as a wound dressing. The FTIR, XRD, and thermal analyses show that AX, SA, and GS interacted through hydrogen bonding and were thermally stable. The AXSA film displays desirable wound dressing characteristics: transparency, uniform thickness, smooth surface mor-phology, tensile strength similar to human skin, mild water/exudate uptake capacity, water transmission rate suitable for wound dressing, and excellent cytocompatibility. In Franz diffusion release studies, >80% GS was released from AXSA films in two phases in 24 h following the Fickian diffusion mechanism. In disk diffusion assay, the AXSA films demonstrated excellent antibacterial effect against E.coli, S. aureus, and P. aeruginosa. Overall, the findings suggest that GS-loaded AXSA films hold potential for further development as antibacterial wound dressing material.
KW - Antibacterial dressing
KW - Arabinoxylan
KW - Drug delivery
KW - Sodium alginate
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85125997551&partnerID=8YFLogxK
U2 - 10.3390/ijms23052899
DO - 10.3390/ijms23052899
M3 - Article
C2 - 35270041
AN - SCOPUS:85125997551
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 5
M1 - 2899
ER -