Determination of the complete absolute configuration of petriellin A

Luigi Aurelio, Robert T.C. Brownlee, Jason Dang, Andrew B. Hughes, Gideon M. Polya

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6 Citations (Scopus)

Abstract

We report the full structural determination of the depsipeptide petriellin A. The absolute configuration of the amino acid residues, N-methyl isoleucine and N-methyl threonine, have been determined by a combination of HPLC and TLC comparison of synthetic Marfey's derivatives and Marfey's derivatives of the natural product hydrolysate. The configuration of the chiral centres in these two N-methylated residues was found to be the same as those of the common unmethylated l-amino acids.

Original languageEnglish
Pages (from-to)407-414
Number of pages8
JournalAustralian Journal of Chemistry
Volume59
Issue number6
DOIs
Publication statusPublished - 14 Jul 2006

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