Determination of metformin in fixed-dose combination tablets by ATR-FTIR spectroscopy

B. A. Sabbagh; P. V. Kumar; Y. L. Chew; J. H. Chin; G. A. Akowuah

doi:10.1016/j.cdc.2022.100868

Determination of metformin in fixed-dose combination tablets by ATR-FTIR spectroscopy

B. A. Sabbagh, P. V. Kumar, Y. L. Chew, J. H. Chin, G. A. Akowuah

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

This study describes the determination of metformin in fixed-dose combination (FDC) tablets using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Metformin standard concentrations ranging from 10 to 100% w/w were prepared by diluting with potassium bromide (KBr). Prediction model was developed using partial least squares (PLS) based on the ATR-FTIR spectral region 1066.50–1052.47 cm⁻¹. The results of the model showed good linearity with a regression coefficient (R²) of 0.9997. The root mean square error of calibration (RMSEC) was 0.447. Three commercial FDC drugs containing 500 mg metformin/tablet were quantified. The accuracy of the metformin quantification in the FDC tablets was 100% ± 2. The developed ATR-FTIR method is suitable for the routine determination of metformin in FDC tablets and other pharmaceutical formulations.

Original language	English
Article number	100868
Number of pages	7
Journal	Chemical Data Collections
Volume	39
DOIs	https://doi.org/10.1016/j.cdc.2022.100868
Publication status	Published - Jun 2022
Externally published	Yes

Keywords

Attenuated total reflectance Fourier transform infrared
Diabetic management
Fixed-dose combination tablet
Metformin
Partial least square regression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cdc.2022.100868

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title = "Determination of metformin in fixed-dose combination tablets by ATR-FTIR spectroscopy",

abstract = "This study describes the determination of metformin in fixed-dose combination (FDC) tablets using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Metformin standard concentrations ranging from 10 to 100% w/w were prepared by diluting with potassium bromide (KBr). Prediction model was developed using partial least squares (PLS) based on the ATR-FTIR spectral region 1066.50–1052.47 cm−1. The results of the model showed good linearity with a regression coefficient (R2) of 0.9997. The root mean square error of calibration (RMSEC) was 0.447. Three commercial FDC drugs containing 500 mg metformin/tablet were quantified. The accuracy of the metformin quantification in the FDC tablets was 100% ± 2. The developed ATR-FTIR method is suitable for the routine determination of metformin in FDC tablets and other pharmaceutical formulations.",

keywords = "Attenuated total reflectance Fourier transform infrared, Diabetic management, Fixed-dose combination tablet, Metformin, Partial least square regression",

author = "Sabbagh, {B. A.} and Kumar, {P. V.} and Chew, {Y. L.} and Chin, {J. H.} and Akowuah, {G. A.}",

note = "Funding Information: The research work was financially supported by UCSI University Research Grant Scheme (Proj-In-FPS-025) awarded by the centre of Excellence for Research, Value Innovation and Entrepreneurship (CERVIE), UCSI University. Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jun,

doi = "10.1016/j.cdc.2022.100868",

language = "English",

volume = "39",

journal = "Chemical Data Collections",

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AU - Sabbagh, B. A.

AU - Kumar, P. V.

AU - Chew, Y. L.

AU - Chin, J. H.

AU - Akowuah, G. A.

N1 - Funding Information: The research work was financially supported by UCSI University Research Grant Scheme (Proj-In-FPS-025) awarded by the centre of Excellence for Research, Value Innovation and Entrepreneurship (CERVIE), UCSI University. Publisher Copyright: © 2022

PY - 2022/6

Y1 - 2022/6

N2 - This study describes the determination of metformin in fixed-dose combination (FDC) tablets using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Metformin standard concentrations ranging from 10 to 100% w/w were prepared by diluting with potassium bromide (KBr). Prediction model was developed using partial least squares (PLS) based on the ATR-FTIR spectral region 1066.50–1052.47 cm−1. The results of the model showed good linearity with a regression coefficient (R2) of 0.9997. The root mean square error of calibration (RMSEC) was 0.447. Three commercial FDC drugs containing 500 mg metformin/tablet were quantified. The accuracy of the metformin quantification in the FDC tablets was 100% ± 2. The developed ATR-FTIR method is suitable for the routine determination of metformin in FDC tablets and other pharmaceutical formulations.

AB - This study describes the determination of metformin in fixed-dose combination (FDC) tablets using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Metformin standard concentrations ranging from 10 to 100% w/w were prepared by diluting with potassium bromide (KBr). Prediction model was developed using partial least squares (PLS) based on the ATR-FTIR spectral region 1066.50–1052.47 cm−1. The results of the model showed good linearity with a regression coefficient (R2) of 0.9997. The root mean square error of calibration (RMSEC) was 0.447. Three commercial FDC drugs containing 500 mg metformin/tablet were quantified. The accuracy of the metformin quantification in the FDC tablets was 100% ± 2. The developed ATR-FTIR method is suitable for the routine determination of metformin in FDC tablets and other pharmaceutical formulations.

KW - Attenuated total reflectance Fourier transform infrared

KW - Diabetic management

KW - Fixed-dose combination tablet

KW - Metformin

KW - Partial least square regression

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DO - 10.1016/j.cdc.2022.100868

M3 - Article

AN - SCOPUS:85129180143

SN - 2405-8300

VL - 39

JO - Chemical Data Collections

JF - Chemical Data Collections

M1 - 100868

ER -

Determination of metformin in fixed-dose combination tablets by ATR-FTIR spectroscopy

Abstract

Keywords

UN SDGs

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