Determinants of virological failure after 1 year's antiretroviral therapy in Vietnamese people with HIV: findings from a retrospective cohort of 13 outpatient clinics in six provinces

Dam Anh Tran, David P. Wilson, Anthony Shakeshaft, Anh Duc Ngo, Christopher Doran, Lei Zhang

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Objective: This study examines the proportions and causes of virological failure after one year of antiretroviral therapy (ART) among people living with HIV (PLHIV) in Vietnam. It also evaluates the positive predictive value (PPV) of immunological criteria to detect treatment failure. 

Method: A retrospective cohort of 3449 people with HIV who started ART between 1 January 2005 and 31 December 2009 in 13 outpatient clinics in Vietnam was studied. Multivariate logistic regression modeling was used to calculate crude and adjusted ORs and 95% CIs for associations between patient characteristics and virological failure. 

Results: An estimated 6.5% (226/3449) of HIV patients in the participating clinics in Vietnam had confirmed virological failure one year after the start of ART. After adjusting for other factors, patients with a baseline CD4 count of 50-100 cells/mm3 and 101-200 cells/mm3 were statistically significantly less likely to have virological failure, compared to those with a baseline CD4 count lower than 50 cells/mm3 (OR=0.61, 95% CI 0.23-0.89; and OR=0.43, 0.18-0.78, respectively). In contrast, patients with a history of injecting drug use were statistically significantly more likely to have viraemia than otherwise (OR=1.32, 1.16-1.67). The PPV of the WHO immunological criteria was 60.1% (57.1-69.3%). 

Conclusions: Routine viral load tests should be conducted early to detect virological failure and prevent unnecessary changes to second-line treatments. To improve treatment outcomes, timely ART initiation and adherence to treatment among those with history of injecting drug use should be promoted.

Original languageEnglish
Pages (from-to)538-544
Number of pages7
JournalSexually Transmitted Infections
Volume90
Issue number7
DOIs
Publication statusPublished - Nov 2014
Externally publishedYes

Cite this

@article{9dc45e8c360c4468b78c28eb65251ad9,
title = "Determinants of virological failure after 1 year's antiretroviral therapy in Vietnamese people with HIV: findings from a retrospective cohort of 13 outpatient clinics in six provinces",
abstract = "Objective: This study examines the proportions and causes of virological failure after one year of antiretroviral therapy (ART) among people living with HIV (PLHIV) in Vietnam. It also evaluates the positive predictive value (PPV) of immunological criteria to detect treatment failure. Method: A retrospective cohort of 3449 people with HIV who started ART between 1 January 2005 and 31 December 2009 in 13 outpatient clinics in Vietnam was studied. Multivariate logistic regression modeling was used to calculate crude and adjusted ORs and 95{\%} CIs for associations between patient characteristics and virological failure. Results: An estimated 6.5{\%} (226/3449) of HIV patients in the participating clinics in Vietnam had confirmed virological failure one year after the start of ART. After adjusting for other factors, patients with a baseline CD4 count of 50-100 cells/mm3 and 101-200 cells/mm3 were statistically significantly less likely to have virological failure, compared to those with a baseline CD4 count lower than 50 cells/mm3 (OR=0.61, 95{\%} CI 0.23-0.89; and OR=0.43, 0.18-0.78, respectively). In contrast, patients with a history of injecting drug use were statistically significantly more likely to have viraemia than otherwise (OR=1.32, 1.16-1.67). The PPV of the WHO immunological criteria was 60.1{\%} (57.1-69.3{\%}). Conclusions: Routine viral load tests should be conducted early to detect virological failure and prevent unnecessary changes to second-line treatments. To improve treatment outcomes, timely ART initiation and adherence to treatment among those with history of injecting drug use should be promoted.",
author = "Tran, {Dam Anh} and Wilson, {David P.} and Anthony Shakeshaft and Ngo, {Anh Duc} and Christopher Doran and Lei Zhang",
year = "2014",
month = "11",
doi = "10.1136/sextrans-2013-051353",
language = "English",
volume = "90",
pages = "538--544",
journal = "Sexually Transmitted Infections",
issn = "1368-4973",
publisher = "BMJ Group",
number = "7",

}

Determinants of virological failure after 1 year's antiretroviral therapy in Vietnamese people with HIV : findings from a retrospective cohort of 13 outpatient clinics in six provinces. / Tran, Dam Anh; Wilson, David P.; Shakeshaft, Anthony; Ngo, Anh Duc; Doran, Christopher; Zhang, Lei.

In: Sexually Transmitted Infections, Vol. 90, No. 7, 11.2014, p. 538-544.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Determinants of virological failure after 1 year's antiretroviral therapy in Vietnamese people with HIV

T2 - findings from a retrospective cohort of 13 outpatient clinics in six provinces

AU - Tran, Dam Anh

AU - Wilson, David P.

AU - Shakeshaft, Anthony

AU - Ngo, Anh Duc

AU - Doran, Christopher

AU - Zhang, Lei

PY - 2014/11

Y1 - 2014/11

N2 - Objective: This study examines the proportions and causes of virological failure after one year of antiretroviral therapy (ART) among people living with HIV (PLHIV) in Vietnam. It also evaluates the positive predictive value (PPV) of immunological criteria to detect treatment failure. Method: A retrospective cohort of 3449 people with HIV who started ART between 1 January 2005 and 31 December 2009 in 13 outpatient clinics in Vietnam was studied. Multivariate logistic regression modeling was used to calculate crude and adjusted ORs and 95% CIs for associations between patient characteristics and virological failure. Results: An estimated 6.5% (226/3449) of HIV patients in the participating clinics in Vietnam had confirmed virological failure one year after the start of ART. After adjusting for other factors, patients with a baseline CD4 count of 50-100 cells/mm3 and 101-200 cells/mm3 were statistically significantly less likely to have virological failure, compared to those with a baseline CD4 count lower than 50 cells/mm3 (OR=0.61, 95% CI 0.23-0.89; and OR=0.43, 0.18-0.78, respectively). In contrast, patients with a history of injecting drug use were statistically significantly more likely to have viraemia than otherwise (OR=1.32, 1.16-1.67). The PPV of the WHO immunological criteria was 60.1% (57.1-69.3%). Conclusions: Routine viral load tests should be conducted early to detect virological failure and prevent unnecessary changes to second-line treatments. To improve treatment outcomes, timely ART initiation and adherence to treatment among those with history of injecting drug use should be promoted.

AB - Objective: This study examines the proportions and causes of virological failure after one year of antiretroviral therapy (ART) among people living with HIV (PLHIV) in Vietnam. It also evaluates the positive predictive value (PPV) of immunological criteria to detect treatment failure. Method: A retrospective cohort of 3449 people with HIV who started ART between 1 January 2005 and 31 December 2009 in 13 outpatient clinics in Vietnam was studied. Multivariate logistic regression modeling was used to calculate crude and adjusted ORs and 95% CIs for associations between patient characteristics and virological failure. Results: An estimated 6.5% (226/3449) of HIV patients in the participating clinics in Vietnam had confirmed virological failure one year after the start of ART. After adjusting for other factors, patients with a baseline CD4 count of 50-100 cells/mm3 and 101-200 cells/mm3 were statistically significantly less likely to have virological failure, compared to those with a baseline CD4 count lower than 50 cells/mm3 (OR=0.61, 95% CI 0.23-0.89; and OR=0.43, 0.18-0.78, respectively). In contrast, patients with a history of injecting drug use were statistically significantly more likely to have viraemia than otherwise (OR=1.32, 1.16-1.67). The PPV of the WHO immunological criteria was 60.1% (57.1-69.3%). Conclusions: Routine viral load tests should be conducted early to detect virological failure and prevent unnecessary changes to second-line treatments. To improve treatment outcomes, timely ART initiation and adherence to treatment among those with history of injecting drug use should be promoted.

UR - http://www.scopus.com/inward/record.url?scp=84911381589&partnerID=8YFLogxK

U2 - 10.1136/sextrans-2013-051353

DO - 10.1136/sextrans-2013-051353

M3 - Article

C2 - 24619575

AN - SCOPUS:84911381589

VL - 90

SP - 538

EP - 544

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

SN - 1368-4973

IS - 7

ER -