TY - JOUR
T1 - Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty
AU - Grigg, Leeanne E.
AU - Kay, Thomas W.H.
AU - Valentine, Peter A.
AU - Larkins, Richard
AU - Flower, Dorothy J.
AU - Manolas, Emmanuel G.
AU - O'Dea, Kerin
AU - Sinclair, Andrew J.
AU - Hopper, John L.
AU - Hunt, David
PY - 1989/3/1
Y1 - 1989/3/1
N2 - The effect of an eicosapentaenoic acid-rich encapsulated preparation of fish oil on the incidence of early restenosis after coronary angioplasty was assessed by a randomized double-blind placebo-controlled study. A total of 108 patients received either 10 capsules of fish oil (1.8 g eicosapentaenoic acid, 1.2 g docosahexaenoic acid) or 10 control capsules (50% olive oil, 50% corn oil), commencing the day before angioplasty and continuing for 4 months after angioplasty, in addition to treatment with aspirin and verapamil. In 101(94%) of the 108 patients, follow-up angiographic or postmortem result was evaluated at a mean (±SD) of 100 (±22) days. Angiographic restenosis was observed in 34% of patients (29% of lesions) in the fish oil-treated group and 33% of patients (31% of lesions) in the control group (no significant difference). The overall incidence of angiographic restenosis was significantly higher in patients with 1) recurrent angina pectoris, 2) a positive exercise test at follow-up after angioplasty, 3) residual stenosis >30% immediately after angioplasty, and 4) dilation of the left anterior descending or right coronary artery. Biochemical investigations showed a greater decrease in the serum triglyceride levels in the fish oil-treated group versus the control group (p < 0.05) but no differences between the two groups in cholesterol levels or platelet counts over the 4 month period. In conclusion, in this study, the administration of fish oil at a dose of 10 capsules/day did not reduce the incidence of early restenosis after coronary angioplasty.
AB - The effect of an eicosapentaenoic acid-rich encapsulated preparation of fish oil on the incidence of early restenosis after coronary angioplasty was assessed by a randomized double-blind placebo-controlled study. A total of 108 patients received either 10 capsules of fish oil (1.8 g eicosapentaenoic acid, 1.2 g docosahexaenoic acid) or 10 control capsules (50% olive oil, 50% corn oil), commencing the day before angioplasty and continuing for 4 months after angioplasty, in addition to treatment with aspirin and verapamil. In 101(94%) of the 108 patients, follow-up angiographic or postmortem result was evaluated at a mean (±SD) of 100 (±22) days. Angiographic restenosis was observed in 34% of patients (29% of lesions) in the fish oil-treated group and 33% of patients (31% of lesions) in the control group (no significant difference). The overall incidence of angiographic restenosis was significantly higher in patients with 1) recurrent angina pectoris, 2) a positive exercise test at follow-up after angioplasty, 3) residual stenosis >30% immediately after angioplasty, and 4) dilation of the left anterior descending or right coronary artery. Biochemical investigations showed a greater decrease in the serum triglyceride levels in the fish oil-treated group versus the control group (p < 0.05) but no differences between the two groups in cholesterol levels or platelet counts over the 4 month period. In conclusion, in this study, the administration of fish oil at a dose of 10 capsules/day did not reduce the incidence of early restenosis after coronary angioplasty.
UR - http://www.scopus.com/inward/record.url?scp=0024512298&partnerID=8YFLogxK
U2 - 10.1016/0735-1097(89)90609-8
DO - 10.1016/0735-1097(89)90609-8
M3 - Article
C2 - 2537349
AN - SCOPUS:0024512298
SN - 0735-1097
VL - 13
SP - 665
EP - 672
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 3
ER -