Deterioration in Renal function is associated with increased arterial stiffness

Merrill F. Elias, Adam Davey, Gregory A. Dore, Avrum Gillespie, Walter P. Abhayaratna, Michael A. Robbins

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Background Higher levels of baseline pulse wave velocity (PWV) have been associated with longitudinal decline in renal function in patients with kidney disease. We examined longitudinal decline in renal function in relation to levels of PWV. We hypothesized that longitudinal decline in renal function in a community-based, nonclinic sample would be associated with higher levels of PWV. METHODS We conducted a 4-5 year longitudinal study with 482 community-living individuals free from acute stroke, dementia, and end-stage renal disease (mean age = 60.9 years; 59% women; 93.2% white; 10% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) = 79.2ml/min/1.73 m2). Multiple linear regression analyses were used to examine the association between changes in renal function (eGFR and serum creatinine) from baseline to follow-up and PWV levels at follow-up, the outcome measure. Regression coefficients were adjusted for age, sex, education, race/ethnicity, weight, activity level, mean arterial pressure, treatment of hypertension, and cardiovascular risk factors.RESULTS With adjustment for covariables, decline in renal function was associated with higher levels of PWV over a mean follow-up of 4.68 years.CONCLUSIONS Decline in renal functioning from baseline levels measured 4-5 years before measurement of PWV is related to higher levels of PWV in a community sample.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalAmerican Journal of Hypertension
Issue number2
Publication statusPublished - Feb 2014
Externally publishedYes


  • blood pressure
  • cardiovascular disease
  • chronic kidney disease
  • estimated glomerular filtration rate
  • hypertension
  • pulse wave velocity
  • renal disease.

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