Detector technologies for comprehensive two-dimensional gas chromatography

Carin von Muhlen, Weeraya Khummueng, Claudia Zini, Elina Caramao, Philip Marriott

Research output: Contribution to journalShort ReviewOtherpeer-review

44 Citations (Scopus)


The detector is an integral and important part of any chromatographic system. The chromatographic peak profiles (i.e. peak separation) should, ideally, be unaffected by the detector - it should only provide the sensing capacity required at the end of a column separation process. The relatively new technique of comprehensive 2-D GC (GC x GC) extends the performance of GC manyfold, but comes at a price - existing GC systems may not be adequately designed with the requirements of GC x GC in mind. This is primarily the need for precise measurement of very fast peaks entering the detector (e.g. as fast as 50 ms basewidth in some instances). The capacity of the detector to closely track a rapidly changing chromatographic peak profile depends on a number of factors, such as design of flow paths and make-up gas introduction, type of detector response mechanism, and the chemistry of the response. These factors are discussed here as a means to appreciate the technical demands of detection in GC x GC.
Original languageEnglish
Pages (from-to)1909 - 1921
Number of pages13
JournalJournal of Separation Science
Issue number12
Publication statusPublished - 2006
Externally publishedYes

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