Detection of phospholipid-carbon nanotube translocation using fluorescence energy transfer

Sijie Lin; Gayatri Keskar; Yonnie Wu; Xi Wang; Andrew S. Mount; Stephen J. Klaine; Jessica M. Moore; Apparao M. Rao; Pu Chun Ke

doi:10.1063/1.2360228

Detection of phospholipid-carbon nanotube translocation using fluorescence energy transfer

Sijie Lin, Gayatri Keskar, Yonnie Wu, Xi Wang, Andrew S. Mount, Stephen J. Klaine, Jessica M. Moore, Apparao M. Rao, Pu Chun Ke

Research output: Contribution to journal › Article › Research › peer-review

44 Citations (Scopus)

Abstract

Single-walled carbon nanotubes (SWNTs) and lysophospholipids readily assemble into supramolecular complexes in aqueous solutions. Upon light excitation the fluorescence of rhodamine-labeled lysophospholipids was redshifted and quenched due to the optical absorption of the SWNTs. Utilizing fluorescence energy transfer, the authors detected the translocation and disassembly of SWNT complexes in MCF breast cancer cells. These lipid-coated SWNT complexes enable drugs to be delivered at an effective dose and their subsequent release to be monitored in real time.

Original language	English
Article number	143118
Journal	Applied Physics Letters
Volume	89
Issue number	14
DOIs	https://doi.org/10.1063/1.2360228
Publication status	Published - 12 Oct 2006
Externally published	Yes

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10.1063/1.2360228

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AU - Lin, Sijie

AU - Keskar, Gayatri

AU - Wu, Yonnie

AU - Wang, Xi

AU - Mount, Andrew S.

AU - Klaine, Stephen J.

AU - Moore, Jessica M.

AU - Rao, Apparao M.

AU - Ke, Pu Chun

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Y1 - 2006/10/12

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AB - Single-walled carbon nanotubes (SWNTs) and lysophospholipids readily assemble into supramolecular complexes in aqueous solutions. Upon light excitation the fluorescence of rhodamine-labeled lysophospholipids was redshifted and quenched due to the optical absorption of the SWNTs. Utilizing fluorescence energy transfer, the authors detected the translocation and disassembly of SWNT complexes in MCF breast cancer cells. These lipid-coated SWNT complexes enable drugs to be delivered at an effective dose and their subsequent release to be monitored in real time.

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VL - 89

JO - Applied Physics Letters

JF - Applied Physics Letters

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ER -

Detection of phospholipid-carbon nanotube translocation using fluorescence energy transfer

Abstract

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