A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 29 Sep 2003|
- Analytical methods
- Combinatorial chemistry
- Medicinal chemistry
- X-ray diffraction