Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O'Reilly, Paul G. Wyatt, Harren Jhoti

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Abstract

A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.

Original languageEnglish
Pages (from-to)4479-4482
Number of pages4
JournalAngewandte Chemie - International Edition
Volume42
Issue number37
DOIs
Publication statusPublished - 29 Sep 2003
Externally publishedYes

Keywords

  • Analytical methods
  • Combinatorial chemistry
  • Medicinal chemistry
  • Proteins
  • X-ray diffraction

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