Abstract
A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.
Original language | English |
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Pages (from-to) | 4479-4482 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 42 |
Issue number | 37 |
DOIs | |
Publication status | Published - 29 Sep 2003 |
Externally published | Yes |
Keywords
- Analytical methods
- Combinatorial chemistry
- Medicinal chemistry
- Proteins
- X-ray diffraction