Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Miles S. Congreve; Deborah J. Davis; Lindsay Devine; Cesare Granata; Marc O'Reilly; Paul G. Wyatt; Harren Jhoti

doi:10.1002/anie.200351951

Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Miles S. Congreve, Deborah J. Davis, Lindsay Devine, Cesare Granata, Marc O'Reilly, Paul G. Wyatt, Harren Jhoti

Research output: Contribution to journal › Article › Research › peer-review

89 Citations (Scopus)

Abstract

A dynamic combinatorial library of ligands derived from hydrazines A and isatins B was assembled in the presence of crystals of the target protein, cyclin-dependent kinase 2 (CDK2). Unambiguous detection of potent ligands, formed as part of the library, was successfully achieved by X-ray crystallographic analysis.

Original language	English
Pages (from-to)	4479-4482
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	37
DOIs	https://doi.org/10.1002/anie.200351951
Publication status	Published - 29 Sep 2003
Externally published	Yes

Keywords

Analytical methods
Combinatorial chemistry
Medicinal chemistry
Proteins
X-ray diffraction

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10.1002/anie.200351951

Cite this

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AU - Wyatt, Paul G.

AU - Jhoti, Harren

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KW - Medicinal chemistry

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KW - X-ray diffraction

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Detection of ligands from a dynamic combinatorial library by X-ray crystallography

Abstract

Keywords

Access to Document

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