Detection of anti-yellow fever virus immunoglobulin m antibodies at 3-4 years following yellow fever vaccination

Katherine Gibney, Srilatha Edupuganti, Amanda J Panella, Olga I Kosoy, Mark J Delorey, Robert Lanciotti, Mark J Mulligan, Marc Fischer, J Erin Staples

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Abstract

The duration of anti-yellow fever (YF) virus immunoglobulin M (IgM) antibodies following YF vaccination is unknown, making it difficult to interpret positive IgM antibody results in previously vaccinated travelers. We evaluated the frequency and predictors of YF IgM antibody positivity 3-4 years following YF vaccination. Twenty-nine (73 ) of 40 participants had YF IgM antibodies 3-4 years postvaccination. No demographic or exposure variables were predictive of YF IgM positivity. However, persons who were YF IgM positive at 3-4 years postvaccination had earlier onset viremia and higher neutralizing antibody geometric mean titers at 1 month and 3-4 years postvaccination compared with persons who were YF IgM negative. Detection of YF IgM antibodies several years postvaccination might reflect remote YF vaccination rather than recent YF vaccination or YF virus infection.
Original languageEnglish
Pages (from-to)1112 - 1115
Number of pages4
JournalThe American Journal of Tropical Medicine and Hygiene
Volume87
Issue number6
DOIs
Publication statusPublished - 2012

Cite this

Gibney, K., Edupuganti, S., Panella, A. J., Kosoy, O. I., Delorey, M. J., Lanciotti, R., Mulligan, M. J., Fischer, M., & Staples, J. E. (2012). Detection of anti-yellow fever virus immunoglobulin m antibodies at 3-4 years following yellow fever vaccination. The American Journal of Tropical Medicine and Hygiene, 87(6), 1112 - 1115. https://doi.org/10.4269/ajtmh.2012.12-0182