Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies

Katie Ardipradja, Shinn Dee Yeoh, Karen Alt, Graeme J O'Keefe, Angela Rigopoulos, David William Howells, Andrew Mark Scott, Karlheinz Peter, Uwe Ackermann, Christoph E Hagemeyer

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies (scFv) against ligand-induced binding sites (LIBS) on the highly abundant platelet glycoprotein integrin receptor IIb/IIIa. The aim of this study was the construction and characterisation of a novel 18F PET radiotracer based on this antibody.
Original languageEnglish
Pages (from-to)229 - 237
Number of pages9
JournalNuclear Medicine and Biology
Volume41
Issue number3
DOIs
Publication statusPublished - 2014

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