Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies

Katie Ardipradja, Shinn Dee Yeoh, Karen Alt, Graeme J O'Keefe, Angela Rigopoulos, David William Howells, Andrew Mark Scott, Karlheinz Peter, Uwe Ackermann, Christoph E Hagemeyer

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies (scFv) against ligand-induced binding sites (LIBS) on the highly abundant platelet glycoprotein integrin receptor IIb/IIIa. The aim of this study was the construction and characterisation of a novel 18F PET radiotracer based on this antibody.
Original languageEnglish
Pages (from-to)229 - 237
Number of pages9
JournalNuclear Medicine and Biology
Volume41
Issue number3
DOIs
Publication statusPublished - 2014

Cite this

Ardipradja, Katie ; Yeoh, Shinn Dee ; Alt, Karen ; O'Keefe, Graeme J ; Rigopoulos, Angela ; Howells, David William ; Scott, Andrew Mark ; Peter, Karlheinz ; Ackermann, Uwe ; Hagemeyer, Christoph E. / Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies. In: Nuclear Medicine and Biology. 2014 ; Vol. 41, No. 3. pp. 229 - 237.
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abstract = "Activated platelets are key players in thrombosis and inflammation. We previously generated single-chain antibodies (scFv) against ligand-induced binding sites (LIBS) on the highly abundant platelet glycoprotein integrin receptor IIb/IIIa. The aim of this study was the construction and characterisation of a novel 18F PET radiotracer based on this antibody.",
author = "Katie Ardipradja and Yeoh, {Shinn Dee} and Karen Alt and O'Keefe, {Graeme J} and Angela Rigopoulos and Howells, {David William} and Scott, {Andrew Mark} and Karlheinz Peter and Uwe Ackermann and Hagemeyer, {Christoph E}",
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Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies. / Ardipradja, Katie; Yeoh, Shinn Dee; Alt, Karen; O'Keefe, Graeme J; Rigopoulos, Angela; Howells, David William; Scott, Andrew Mark; Peter, Karlheinz; Ackermann, Uwe; Hagemeyer, Christoph E.

In: Nuclear Medicine and Biology, Vol. 41, No. 3, 2014, p. 229 - 237.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Rigopoulos, Angela

AU - Howells, David William

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