Projects per year
Abstract
Background: Transcriptional regulation is primarily mediated by the binding of factors to non-coding regions in DNA. Identification of these binding regions enhances understanding of tissue formation and potentially facilitates the development of gene therapies. However, successful identification of binding regions is made difficult by the lack of a universal biological code for their characterisation. Results: We extend an alignment-based method, changept, and identify clusters of biological significance, through ontology and de novo motif analysis. Further, we apply a Bayesian method to estimate and combine binary classifiers on the clusters we identify to produce a better performing composite. Conclusions: The analysis we describe provides a computational method for identification of conserved binding sites in the human genome and facilitates an alternative interrogation of combinations of existing data sets with alignment data.
Original language | English |
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Article number | 78 |
Number of pages | 16 |
Journal | BMC Genomics |
Volume | 23 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 2022 |
Keywords
- Bayesian modelling
- Conserved non-coding sequences
- Genome segmentation
- Putative functional elements
Projects
- 4 Finished
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Formation of boundaries in the developing embryo
Ramialison, M., Nguyen, L. & Bakkers, J.
10/06/19 → 31/12/22
Project: Research
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ARC Centre of Excellence for Mathematical and Statistical Frontiers of Big Data, Big Models, New Insights
Hall, P., Bartlett, P., Bean, N., Burrage, K., DeGier, J., Delaigle, A., Forrester, P., Geweke, J., Kohn, R., Kroese, D., Mengersen, K. L., Pettit, A., Pollett, P., Roughan, M., Ryan, L. M., Taylor, P., Turner, I., Wand, M., Garoni, T., Smith-Miles, K. A., Caley, M., Churches, T., Elazar, D., Gupta, A., Harch, B., Tam, S., Weegberg, K., Willinger, W. & Hyndman, R.
Australian Research Council (ARC), Monash University – Internal Department Contribution, University of Melbourne, Queensland University of Technology (QUT), University of Adelaide, University of New South Wales (UNSW), University of Queensland , University of Technology (UTS) Sydney, Monash University – Internal University Contribution, Monash University – Internal Faculty Contribution, Monash University – Internal School Contribution, Roads Corporation (trading as VicRoads) (Victoria)
1/01/17 → 31/12/21
Project: Research
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Experimentally validated multiphase mathematical models of leg ulcers
Flegg, J.
Australian Research Council (ARC)
15/08/16 → 1/05/17
Project: Research