Detecting brain injury in neonatal hypoxic ischemic encephalopathy: Closing the gap between experimental and clinical research

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Abstract

Moderate to severe neonatal hypoxic ischemic encephalopathy remains an important cause of infant death and childhood disability. Early and accurate diagnosis of encephalopathy is difficult but critical for timely intervention. Thus, we have utilized a clinically relevant large animal model of asphyxia in-utero, followed by immediate lamb delivery, resuscitation and clinical care over the next 72 h for assessment of potential biomarkers of brain injury.
Original languageEnglish
Pages (from-to)281 - 290
Number of pages10
JournalExperimental Neurology
Volume261
DOIs
Publication statusPublished - 2014

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