Detecting brain injury in neonatal hypoxic ischemic encephalopathy: Closing the gap between experimental and clinical research

James Aridas, Tamara Yawno, Amy Elizabeth Sutherland, Ilias Nitsos, Michael Ditchfield, Flora Yuen-Wait Wong, Michael Collingwood Fahey, Atul Malhotra, Euan Morrison Wallace, Graham Jenkin, Suzanne Lee Miller

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Moderate to severe neonatal hypoxic ischemic encephalopathy remains an important cause of infant death and childhood disability. Early and accurate diagnosis of encephalopathy is difficult but critical for timely intervention. Thus, we have utilized a clinically relevant large animal model of asphyxia in-utero, followed by immediate lamb delivery, resuscitation and clinical care over the next 72 h for assessment of potential biomarkers of brain injury.
Original languageEnglish
Pages (from-to)281 - 290
Number of pages10
JournalExperimental Neurology
Volume261
DOIs
Publication statusPublished - 2014

Cite this

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title = "Detecting brain injury in neonatal hypoxic ischemic encephalopathy: Closing the gap between experimental and clinical research",
abstract = "Moderate to severe neonatal hypoxic ischemic encephalopathy remains an important cause of infant death and childhood disability. Early and accurate diagnosis of encephalopathy is difficult but critical for timely intervention. Thus, we have utilized a clinically relevant large animal model of asphyxia in-utero, followed by immediate lamb delivery, resuscitation and clinical care over the next 72 h for assessment of potential biomarkers of brain injury.",
author = "James Aridas and Tamara Yawno and Sutherland, {Amy Elizabeth} and Ilias Nitsos and Michael Ditchfield and Wong, {Flora Yuen-Wait} and Fahey, {Michael Collingwood} and Atul Malhotra and Wallace, {Euan Morrison} and Graham Jenkin and Miller, {Suzanne Lee}",
year = "2014",
doi = "10.1016/j.expneurol.2014.07.009",
language = "English",
volume = "261",
pages = "281 -- 290",
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Detecting brain injury in neonatal hypoxic ischemic encephalopathy: Closing the gap between experimental and clinical research. / Aridas, James; Yawno, Tamara; Sutherland, Amy Elizabeth; Nitsos, Ilias; Ditchfield, Michael; Wong, Flora Yuen-Wait; Fahey, Michael Collingwood; Malhotra, Atul; Wallace, Euan Morrison; Jenkin, Graham; Miller, Suzanne Lee.

In: Experimental Neurology, Vol. 261, 2014, p. 281 - 290.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Detecting brain injury in neonatal hypoxic ischemic encephalopathy: Closing the gap between experimental and clinical research

AU - Aridas, James

AU - Yawno, Tamara

AU - Sutherland, Amy Elizabeth

AU - Nitsos, Ilias

AU - Ditchfield, Michael

AU - Wong, Flora Yuen-Wait

AU - Fahey, Michael Collingwood

AU - Malhotra, Atul

AU - Wallace, Euan Morrison

AU - Jenkin, Graham

AU - Miller, Suzanne Lee

PY - 2014

Y1 - 2014

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AB - Moderate to severe neonatal hypoxic ischemic encephalopathy remains an important cause of infant death and childhood disability. Early and accurate diagnosis of encephalopathy is difficult but critical for timely intervention. Thus, we have utilized a clinically relevant large animal model of asphyxia in-utero, followed by immediate lamb delivery, resuscitation and clinical care over the next 72 h for assessment of potential biomarkers of brain injury.

UR - http://www.sciencedirect.com/science/article/pii/S0014488614002374

U2 - 10.1016/j.expneurol.2014.07.009

DO - 10.1016/j.expneurol.2014.07.009

M3 - Article

VL - 261

SP - 281

EP - 290

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

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