Designed metal–organic framework based on metal–organic polyhedron: drug delivery

Jian Wu; Jing Wen Xu; Wei Cong Liu; Su Zhen Yang; Miao Miao Luo; Yao Yao Han; Jian Qiang Liu; Stuart R Batten

doi:10.1016/j.inoche.2016.06.023

Designed metal–organic framework based on metal–organic polyhedron: drug delivery

Jian Wu, Jing Wen Xu, Wei Cong Liu, Su Zhen Yang, Miao Miao Luo, Yao Yao Han, Jian Qiang Liu, Stuart R Batten

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

A new metal–organic framework having formula {[NH₂(CH₃)][Cu₆(L)₃(OAc)(H₂O)₄]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.

Original language	English
Pages (from-to)	32-34
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	71
DOIs	https://doi.org/10.1016/j.inoche.2016.06.023
Publication status	Published - 1 Sept 2016

Keywords

Drug delivery
Polyhedral cage
Topology

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10.1016/j.inoche.2016.06.023

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title = "Designed metal–organic framework based on metal–organic polyhedron: drug delivery",

abstract = "A new metal–organic framework having formula \{[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent\} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt\% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98\% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.",

keywords = "Drug delivery, Polyhedral cage, Topology",

author = "Jian Wu and Xu, \{Jing Wen\} and Liu, \{Wei Cong\} and Yang, \{Su Zhen\} and Luo, \{Miao Miao\} and Han, \{Yao Yao\} and Liu, \{Jian Qiang\} and Batten, \{Stuart R\}",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.inoche.2016.06.023",

language = "English",

volume = "71",

pages = "32--34",

journal = "Inorganic Chemistry Communications",

issn = "1387-7003",

publisher = "Elsevier",

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TY - JOUR

T1 - Designed metal–organic framework based on metal–organic polyhedron

T2 - drug delivery

AU - Wu, Jian

AU - Xu, Jing Wen

AU - Liu, Wei Cong

AU - Yang, Su Zhen

AU - Luo, Miao Miao

AU - Han, Yao Yao

AU - Liu, Jian Qiang

AU - Batten, Stuart R

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.

AB - A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.

KW - Drug delivery

KW - Polyhedral cage

KW - Topology

UR - https://www.scopus.com/pages/publications/84977610479

U2 - 10.1016/j.inoche.2016.06.023

DO - 10.1016/j.inoche.2016.06.023

M3 - Article

AN - SCOPUS:84977610479

SN - 1387-7003

VL - 71

SP - 32

EP - 34

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

ER -

Designed metal–organic framework based on metal–organic polyhedron: drug delivery

Abstract

Keywords

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