Abstract
A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.
Original language | English |
---|---|
Pages (from-to) | 32-34 |
Number of pages | 3 |
Journal | Inorganic Chemistry Communications |
Volume | 71 |
DOIs | |
Publication status | Published - 1 Sept 2016 |
Keywords
- Drug delivery
- Polyhedral cage
- Topology