Designed metal–organic framework based on metal–organic polyhedron

drug delivery

Jian Wu, Jing Wen Xu, Wei Cong Liu, Su Zhen Yang, Miao Miao Luo, Yao Yao Han, Jian Qiang Liu, Stuart R Batten

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.

Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalInorganic Chemistry Communication
Volume71
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Drug delivery
  • Polyhedral cage
  • Topology

Cite this

Wu, Jian ; Xu, Jing Wen ; Liu, Wei Cong ; Yang, Su Zhen ; Luo, Miao Miao ; Han, Yao Yao ; Liu, Jian Qiang ; Batten, Stuart R. / Designed metal–organic framework based on metal–organic polyhedron : drug delivery. In: Inorganic Chemistry Communication. 2016 ; Vol. 71. pp. 32-34.
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abstract = "A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt{\%} per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98{\%} of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.",
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Designed metal–organic framework based on metal–organic polyhedron : drug delivery. / Wu, Jian; Xu, Jing Wen; Liu, Wei Cong; Yang, Su Zhen; Luo, Miao Miao; Han, Yao Yao; Liu, Jian Qiang; Batten, Stuart R.

In: Inorganic Chemistry Communication, Vol. 71, 01.09.2016, p. 32-34.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Wu, Jian

AU - Xu, Jing Wen

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AU - Yang, Su Zhen

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AU - Liu, Jian Qiang

AU - Batten, Stuart R

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