Designed metal–organic framework based on metal–organic polyhedron: drug delivery

Jian Wu, Jing Wen Xu, Wei Cong Liu, Su Zhen Yang, Miao Miao Luo, Yao Yao Han, Jian Qiang Liu, Stuart R Batten

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25 Citations (Scopus)

Abstract

A new metal–organic framework having formula {[NH2(CH3)][Cu6(L)3(OAc)(H2O)4]·xsolvent} (H4L = 3,5-bis(isophthalic acid)-1H-1,2,4-triazole) (1) was synthesized, in which two types of polyhedral cages and one-dimensional channels coexist. The incorporation of the drug 5-fluorouracil (5-FU) into the desolvated 1 was around 24.9 wt% per gram of dehydrated 1. 5-FU is released in a controlled and progressive fashion with 98% of the drug released after 120 h at PBS. The result from this work provides a new avenue for MOF to be used as potential drug delivery.

Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalInorganic Chemistry Communications
Volume71
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Drug delivery
  • Polyhedral cage
  • Topology

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