Designed metal-binding sites in biomolecular and bioinorganic interactions

Jacqueline M. Matthews, Fionna E. Loughlin, Joel P. Mackay

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)


The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein-protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.

Original languageEnglish
Pages (from-to)484-490
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number4
Publication statusPublished - 1 Aug 2008
Externally publishedYes

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