TY - JOUR
T1 - Designed metal-binding sites in biomolecular and bioinorganic interactions
AU - Matthews, Jacqueline M.
AU - Loughlin, Fionna E.
AU - Mackay, Joel P.
PY - 2008/8/1
Y1 - 2008/8/1
N2 - The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein-protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.
AB - The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein-protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.
UR - http://www.scopus.com/inward/record.url?scp=49549085951&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2008.04.009
DO - 10.1016/j.sbi.2008.04.009
M3 - Review Article
C2 - 18554898
AN - SCOPUS:49549085951
VL - 18
SP - 484
EP - 490
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
IS - 4
ER -