Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M₄ mAChR

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• Active

  ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery

  Sexton, P. (Primary Chief Investigator (PCI)), Rouiller, I. (Chief Investigator (CI)), Wootten, D. (Chief Investigator (CI)), van Oijen, A. (Chief Investigator (CI)), Parker, M. W. (Chief Investigator (CI)), Lucet, I. (Partner Investigator (PI)), Griffin, M. D. W. (Chief Investigator (CI)), Adams, D. J. (Chief Investigator (CI)), Czabotar, P. E. (Partner Investigator (PI)), Flocco, M. (Partner Investigator (PI)), Han, S. (Partner Investigator (PI)), Shepherd, R. (Partner Investigator (PI)), Ciferri, C. (Partner Investigator (PI)), Williams, P. A. (Partner Investigator (PI)), Brown, D. (Partner Investigator (PI)), Schreuder, H. (Partner Investigator (PI)), Reedtz-Runge, S. (Partner Investigator (PI)), Drinkwater, C. (Partner Investigator (PI)), Howard, B. L. (Partner Investigator (PI)), Betigeri, G. (Partner Investigator (PI)), Pryor, E. (Partner Investigator (PI)), How, J. (Project Manager) & Christopoulos, T. (Chief Investigator (CI))

  Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)

  23/03/21 → 23/03/27

  Project: Research

• Using protein structure and dynamics to facilitate drug discovery

  Thal, D. (Primary Chief Investigator (PCI))

  1/01/21 → 31/12/25

  Project: Research

• Finished

  Discovering novel allosteric probes of muscarinic acetylcholine receptors

  Valant, C. (Primary Chief Investigator (PCI)), Scammells, P. (Chief Investigator (CI)) & Christopoulos, A. (Chief Investigator (CI))

  3/06/19 → 31/12/22

  Project: Research

• Translating membrane proteins into therapeutics; from bedside to bench

  Sexton, P. (Primary Chief Investigator (PCI)), Christopoulos, A. (Chief Investigator (CI)), Pantelis, C. (Chief Investigator (CI)) & Parton, R. G. (Chief Investigator (CI))

  1/01/19 → 31/12/23

  Project: Research

• Molecular insight into allosteric modulation of G protein-coupled receptors

  Thal, D. (Primary Chief Investigator (PCI))

  ARC - Australian Research Council

  1/01/17 → 31/12/19

  Project: Research

• Allosteric and Bitopic Ligands Acting at G Protein-Coupled Receptors

  Scammells, P. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))

  ARC - Australian Research Council, Monash University

  1/01/16 → 30/06/19

  Project: Research