Design of nanoparticle structures for cancer immunotherapy

Peter Tsirikis, Sue Dong Xiang, Cordelia Selomulya, Magdalena Plebanski

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Cancer is the leading cause of death worldwide. Central to an effective immunotherapeutic treatment is the generation of CD8+ cytotoxic T lymphocyte responses to the malignant cells. Dendritic cells (DCs) are the key target in cancer immunotherapy. DCs recognize pathogens, initiate the immune response, and are capable of cross-presentation for the induction of CD8 T cell responses. DC-based cancer immunotherapies have been in trials in humans. Nanoparticles, as a vaccine carrier, have shown efficacy in antigen delivery by directly targeting DCs. This chapter examines how prophylactic and therapeutic tumor immunities can be achieved using nanoparticles targeting DCs in vivo. Moreover, this review elucidates the differential immunological properties of engineered nanoparticles. Surface morphology, size, shape, and surface functionalization can influence cellular uptake, toxicity, immunogenicity, and the T-helper 1 (Th1)/T-helper 2 (Th2) bias of the immune response. Understanding how nanoparticles with finely tuned properties interact and modulate the immune response will drive the logical development of nanoparticle vaccines to achieve the intended immunological response.

Original languageEnglish
Title of host publicationNanostructures for Cancer Therapy
EditorsAnton Ficai, Alexandru Mihai Grumezescu
Place of PublicationAmsterdam Netherlands
PublisherElsevier
Pages307-328
Number of pages22
ISBN (Electronic)9780323461504
ISBN (Print)9780323461443
DOIs
Publication statusPublished - 14 Apr 2017

Publication series

NameNanostructures in Therapeutic Medicine Series
PublisherElsevier
Volume4

Keywords

  • Adjuvant
  • Cancer immunotherapy
  • Carrier
  • CD8 T cell responses
  • Dendritic cells
  • Nanoparticle
  • Roughness
  • Shape
  • Size
  • Surface functionalization
  • Vaccine delivery

Cite this

Tsirikis, P., Xiang, S. D., Selomulya, C., & Plebanski, M. (2017). Design of nanoparticle structures for cancer immunotherapy. In A. Ficai, & A. M. Grumezescu (Eds.), Nanostructures for Cancer Therapy (pp. 307-328). (Nanostructures in Therapeutic Medicine Series; Vol. 4). Elsevier. https://doi.org/10.1016/B978-0-323-46144-3.00012-X