Design and operation of an automated high-throughput monoclonal antibody facility

Daniel Stuart Layton, Caroline Elizabeth Laverty, Edouard Nice

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Monoclonal antibodies now form a key part of the biochemist?s toolbox, and are important reagents for therapeutic applications. This has resulted in a need for high-throughput production to satisfy the demand from the global community. Manual production involves overwhelming amounts of tissue culture and associated liquid handling steps to achieve high-throughput operation. By contrast, automated systems can readily cope with the numbers required. In this review, we address the development of automated systems, and discuss the pros and cons of their operation.
Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalBiophysical Reviews
Issue number1
Publication statusPublished - 2013

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