Design and fabrication of a biomimetic nanochannel for highly sensitive arginine response in serum samples

Miaomiao Song, Zhongyue Sun, Cuiping Han, Demei Tian, Haibing Li, Lei Jiang

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

Inspired from their biological counterparts, chemical modification of the interior surface of nanochannels with functional molecules may provide a highly efficient means to control ionic or molecular transport through nanochannels. Herein, we have designed and prepared a aldehyde calix[4]arene (C4AH), which was attached to the interior surface of a single nanochannel by using a click reaction, and that showed a high response for arginine (Arg). Furthermore, the nanofluidic sensing system has been challenged with complex matrices containing a high concentration of interfering sequences and serum. Based on this finding, we believe that the artificial nanochannel can be used for practical Arg-sensing devices, and be applied in a biological environment. Arg-sensing devices: An aldehyde calix[4]arene (C4AH) was designed, prepared, and attached to the interior surface of a single nanochannel through a click reaction, and showed a high response for arginine (Arg; see figure). Furthermore, the nanofluidic sensing system has been challenged with complex matrices containing a high concentration of interfering sequences and serum. The artificial nanochannel can be prepared for practical Arg-sensing devices and be applied in a biological environment.

Original languageEnglish
Pages (from-to)7987-7993
Number of pages7
JournalChemistry - A European Journal
Volume20
Issue number26
DOIs
Publication statusPublished - 23 Jun 2014
Externally publishedYes

Keywords

  • arginine
  • calixarene
  • click chemistry
  • nanochannel
  • sensor

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